Potential role of hybrid positron emission tomography in pre-operative assessment of primary salivary gland carcinomas.

Autor:	Karimian S; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Hüllner MW; Faculty of Medicine, University of Zurich, Zurich, Switzerland.; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland., Rupp NJ; Faculty of Medicine, University of Zurich, Zurich, Switzerland.; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Freiberger SN; Faculty of Medicine, University of Zurich, Zurich, Switzerland.; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Broglie MA; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Morand GB; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.; Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Jazyk:	angličtina
Zdroj:	The Journal of laryngology and otology [J Laryngol Otol] 2023 May; Vol. 137 (5), pp. 551-555. Date of Electronic Publication: 2022 Jun 22.
DOI:	10.1017/S0022215122001475
Abstrakt:	Objective: The added value of hybrid positron emission tomography is increasingly recognised in head and neck cancer. However, its potential role in salivary gland carcinomas has been scarcely investigated. Methods: A consecutive cohort of 45 salivary gland carcinoma patients who underwent pre-therapeutic hybrid positron emission tomography and surgical resection was reviewed. This study investigated whether maximum standardised uptake value correlated with tumour phenotype. Results: Tumours of high-grade disease on histology (salivary duct carcinoma, carcinoma ex pleomorphic adenoma) had higher maximum standardised uptake value (Kruskal-Wallis test, p = 0.011) than low-grade tumours (adenoid cystic carcinoma and acinic cell carcinoma). Patients with pathologically confirmed node-positive disease had significantly higher maximum standardised uptake value of the primary tumour than patients with pathologically confirmed node-negative disease (Kruskal-Wallis test, p = 0.012). Conclusion: Maximum standardised uptake value of the primary tumour may guide clinical decision-making in patients with salivary gland carcinomas, as a high maximum standardised uptake value is associated with high-grade tumour histology and the presence of lymph node metastases. Clinicians may consider more aggressive surgery for these patients.
Databáze:	MEDLINE
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