Depression, anxiety, and post-traumatic stress disorder symptoms after hyperemesis gravidarum: a prospective cohort study.

Autor:	Nijsten K; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands.; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., van der Minnen LM; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands., Dean C; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands.; Pregnancy Sickness Support, Bodmin, UK., Bais JMJ; Department of Obstetrics and Gynecology, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands., Ris-Stalpers C; Laboratory of Reproductive Biology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., van Eekelen R; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands., Bremer HA; Department of Obstetrics and Gynecology, Reinier de Graaf Hospital, Delft, The Netherlands., van der Ham DP; Department of Obstetrics and Gynecology, Martini Hospital, Groningen, The Netherlands., Heidema WM; Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands., Huisjes A; Department of Obstetrics and Gynecology, Gelre Hospital, Apeldoorn, The Netherlands., Kleiverda G; Department of Obstetrics and Gynecology, Flevo Hospital, Almere, The Netherlands., Kuppens SM; Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, The Netherlands., van Laar JOEH; Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands., Langenveld J; Department of Obstetrics and Gynecology, Zuyderland Hospital, Heerlen, The Netherlands., van der Made F; Department of Obstetrics and Gynecology, Franciscus Gasthuis, Rotterdam, The Netherlands., Papatsonis D; Department of Obstetrics and Gynecology, Amphia Hospital, Breda, The Netherlands., Pelinck MJ; Department of Obstetrics and Gynecology, Scheper Hospital, Emmen, The Netherlands., Pernet PJ; Department of Obstetrics and Gynecology, Spaarne Gasthuis, Haarlem, The Netherlands., van Rheenen-Flach L; Department of Obstetrics and Gynecology, OLVG, Amsterdam, The Netherlands., Rijnders RJ; Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands., Scheepers HCJ; Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands., Vogelvang T; Department of Obstetrics and Gynecology, Diakonessenhuis, Utrecht, The Netherlands., Mol BW; Department of Obstetrics and Gynecology, Monash University, Clayton, Australia., Olff M; Department of Psychiatry, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; ARQ National Psychotrauma Centre, Diemen, The Netherlands., Roseboom TJ; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands.; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Koot MH; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands., Grooten IJ; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands., Painter RC; Amsterdam University Medical Centers, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 10055-10063. Date of Electronic Publication: 2022 Jun 21.
DOI:	10.1080/14767058.2022.2089550
Abstrakt:	Objective: To determine the prevalence of depression, anxiety, and posttraumatic stress disorder (PTSD) years after hyperemesis gravidarum (HG) and its association with HG severity. Material and Methods: This prospective cohort study consisted of a follow-up of 215 women admitted for HG, who were eligible to participate in a randomized controlled trial and either declined or agreed to be randomized between 2013 and 2016 in 19 hospitals in the Netherlands. Participants completed the Hospital Anxiety and Depression Scale (HADS) six weeks postpartum and during follow-up and the PTSD checklist for DSM-5 (PCL-5) during follow-up. An anxiety or depression score ≥8 is indicative of an anxiety or depression disorder and a PCL-5 ≥ 31 indicative of PTSD. Measures of HG severity were symptom severity (PUQE-24: Pregnancy Unique Quantification of Emesis), weight change, duration of admissions, readmissions, and admissions after the first trimester. Results: About 54/215 participants completed the HADS six weeks postpartum and 73/215 participants completed the follow-up questionnaire, on average 4.5 years later. Six weeks postpartum, 13 participants (24.1%) had an anxiety score ≥8 and 11 participants (20.4%) a depression score ≥8. During follow-up, 29 participants (39.7%) had an anxiety score ≥8, 20 participants (27.4%) a depression score ≥8, and 16 participants (21.9%) a PCL-5 ≥ 31.Multivariable logistic regression analysis showed that for every additional point of the mean PUQE-24 three weeks after inclusion, the likelihood of having an anxiety score ≥8 and PCL-5 ≥ 31 at follow-up increased with OR 1.41 (95% CI: 1.10;1.79) and OR 1.49 (95% CI: 1.06;2.10) respectively. Conclusion: Depression, anxiety, and PTSD symptoms are common years after HG occurred.
Databáze:	MEDLINE
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