Incremental diagnostic value of 18F-Fluetemetamol PET in differential diagnoses of Alzheimer's Disease-related neurodegenerative diseases from an unselected memory clinic cohort.

Autor: Bao YW; Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Room 406, Block K102 Pokfulam Road, Hong Kong SAR, China., Shea YF; Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China., Chiu PK; Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China., Kwan JSK; Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China., Chan FH; Department of Medicine, Queen Mary Hospital, Hong Kong SAR, China., Mak HK; Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Room 406, Block K102 Pokfulam Road, Hong Kong SAR, China. makkf@hku.hk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jun 20; Vol. 12 (1), pp. 10385. Date of Electronic Publication: 2022 Jun 20.
DOI: 10.1038/s41598-022-14532-z
Abstrakt: To evaluate the incremental diagnostic value of 18F-Flutemetamol PET following MRI measurements on an unselected prospective cohort collected from a memory clinic. A total of 84 participants was included in this study. A stepwise study design was performed including initial analysis (based on clinical assessments), interim analysis (revision of initial analysis post-MRI) and final analysis (revision of interim analysis post-18F-Flutemetamol PET). At each time of evaluation, every participant was categorized into SCD, MCI or dementia syndromal group and further into AD-related, non-AD related or non-specific type etiological subgroup. Post 18F-Flutemetamol PET, the significant changes were seen in the syndromal MCI group (57%, p < 0.001) involving the following etiological subgroups: AD-related MCI (57%, p < 0.01) and non-specific MCI (100%, p < 0.0001); and syndromal dementia group (61%, p < 0.0001) consisting of non-specific dementia subgroup (100%, p < 0.0001). In the binary regression model, amyloid status significantly influenced the diagnostic results of interim analysis (p < 0.01). 18F-Flutemetamol PET can have incremental value following MRI measurements, particularly reflected in the change of diagnosis of individuals with unclear etiology and AD-related-suspected patients due to the role in complementing AD-related pathological information.
(© 2022. The Author(s).)
Databáze: MEDLINE
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