Tipping the balance: toward rational combination therapies to overcome venetoclax resistance in mantle cell lymphoma.
Autor: | Thus YJ; Department of Pathology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands.; Cancer Center Amsterdam (CCA), Cancer Biology and Immunology, Target & Therapy Discovery, Amsterdam, The Netherlands., Eldering E; Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands.; Cancer Center Amsterdam (CCA), Cancer Biology and Immunology, Target & Therapy Discovery, Amsterdam, The Netherlands.; Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Cancer Immunology, Amsterdam, The Netherlands., Kater AP; Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands.; Cancer Center Amsterdam (CCA), Cancer Biology and Immunology, Target & Therapy Discovery, Amsterdam, The Netherlands.; Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Spaargaren M; Department of Pathology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands. marcel.spaargaren@amsterdamumc.nl.; Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, The Netherlands. marcel.spaargaren@amsterdamumc.nl.; Cancer Center Amsterdam (CCA), Cancer Biology and Immunology, Target & Therapy Discovery, Amsterdam, The Netherlands. marcel.spaargaren@amsterdamumc.nl. |
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Jazyk: | angličtina |
Zdroj: | Leukemia [Leukemia] 2022 Sep; Vol. 36 (9), pp. 2165-2176. Date of Electronic Publication: 2022 Jun 20. |
DOI: | 10.1038/s41375-022-01627-9 |
Abstrakt: | Mantle cell lymphoma (MCL), an aggressive, but incurable B-cell lymphoma, is genetically characterized by the t(11;14) translocation, resulting in the overexpression of Cyclin D1. In addition, deregulation of the B-cell lymphoma-2 (BCL-2) family proteins BCL-2, B-cell lymphoma-extra large (BCL-X (© 2022. The Author(s).) |
Databáze: | MEDLINE |
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