18 F-FDG and 68  Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models.

Autor: Wang Y; Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, People's Republic of China., Li Y; State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190, China.; School of Engineering Science, University of Chinese Academy of Sciences, Beijing, 100049, China., Han L; Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China., Wang J; State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190, China.; School of Engineering Science, University of Chinese Academy of Sciences, Beijing, 100049, China., Zhang C; Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, People's Republic of China., Qi E; Department of Interventional Ultrasound, The First Medical Centre, Chinese PLA General Hospital, Beijing, People's Republic of China., Zhang D; Department of Interventional Ultrasound, The First Medical Centre, Chinese PLA General Hospital, Beijing, People's Republic of China., Zhang X; Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, People's Republic of China. 345929778@qq.com., Huan Y; State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190, China. huany@lnm.imech.ac.cn.; School of Engineering Science, University of Chinese Academy of Sciences, Beijing, 100049, China. huany@lnm.imech.ac.cn.; Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190, China. huany@lnm.imech.ac.cn., Tian J; Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, People's Republic of China. www9299sss@163.com.
Jazyk: angličtina
Zdroj: BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2022 Jun 20; Vol. 23 (1), pp. 592. Date of Electronic Publication: 2022 Jun 20.
DOI: 10.1186/s12891-022-05537-w
Abstrakt: Purpose: We built a joint replacement loosening model based on the original rabbit model of infection and evaluated the performance characteristics of 18 F-FDG and 68  Ga-FAPI in evaluating infection and loosening.
Methods: After surgery, the rabbits were divided into four groups, with six individuals in the control group and 10 each in the aseptic loosening, S. aureus and S. epidermidis groups. PET/CT and serological examination were performed three times at two-week intervals. After the rabbits were euthanized, micro-CT, tissue pathology, pullout tests and scanning electron microscopy (SEM) were performed.
Results: The pullout test and SEM showed the feasibility of the aseptic loosening model. 18 F-FDG showed similar performance in the control and loosening groups. The SUVmax of the S. aureus group was consistently higher than that of the S. epidermidis group. As for 68  Ga-FAPI, the SUVmax of the control group was lowest in the second week and gradually increased over subsequent weeks. The SUVmax of the loosening group began to exceed that of the control group after the second week. The SUVmax of the S. aureus group in the second week was the lowest among the four groups and increased as the number of weeks increased. The pathology results showed concordance with the performance of PET/CT. Linear regressions between SUVmax and serology showed that 18 F-FDG was positively correlated with CRP and IL-6, while 68  Ga-FAPI revealed negative correlations with CRP and IL-6 in the second week and positive correlations in the sixth week. In addition, the SUVmax and MT(target)V of both 18 F-FDG and 68  Ga-FAPI were negatively correlated with bone volume/trabecular volume (TV) and bone surface area/TV.
Conclusion: In this longitudinal observation, 68  Ga-FAPI showed greater sensitivity than 18 F-FDG in detecting diseases, and 68  Ga-FAPI had no intestinal or muscular uptake. The MT(target)V of 68  Ga-FAPI was larger than that of 18 F-FDG, which meant that 68  Ga-FAPI had the potential to define the scope of lesions more accurately. Finally, the SUVmax of 68  Ga-FAPI could not differentiate between loosening and infection; further study of the diagnostic criteria is warranted.
(© 2022. The Author(s).)
Databáze: MEDLINE
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