The Effect of Lactobacillus plantarum Extracellular Vesicles from Korean Women in Their 20s on Skin Aging.

Autor:	Jo CS; Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Gyeonggi-do, Korea., Myung CH; Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Gyeonggi-do, Korea., Yoon YC; Human & Microbiome Communicating Laboratory, GFC Co., Ltd., Hwasung 18471, Gyeonggi-do, Korea., Ahn BH; Human & Microbiome Communicating Laboratory, GFC Co., Ltd., Hwasung 18471, Gyeonggi-do, Korea., Min JW; Green & Biome Customizing Laboratory, GFC Co., Ltd., Hwasung 18471, Gyeonggi-do, Korea., Seo WS; Human & Microbiome Communicating Laboratory, GFC Co., Ltd., Hwasung 18471, Gyeonggi-do, Korea.; Green & Biome Customizing Laboratory, GFC Co., Ltd., Hwasung 18471, Gyeonggi-do, Korea., Lee DH; Clinical Business Division, Korea Dermatology Research Institute, GFC Co., Ltd., Sungnam 13517, Gyeonggi-do, Korea., Kang HC; Human & Microbiome Communicating Laboratory, GFC Co., Ltd., Hwasung 18471, Gyeonggi-do, Korea.; Green & Biome Customizing Laboratory, GFC Co., Ltd., Hwasung 18471, Gyeonggi-do, Korea., Heo YH; R&D Complex, HK Kolmar Co., Ltd., Seoul 30004, Korea., Choi H; R&D Complex, HK Kolmar Co., Ltd., Seoul 30004, Korea., Hong IK; R&D Complex, HK Kolmar Co., Ltd., Seoul 30004, Korea., Hwang JS; Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Gyeonggi-do, Korea.
Jazyk:	angličtina
Zdroj:	Current issues in molecular biology [Curr Issues Mol Biol] 2022 Jan 21; Vol. 44 (2), pp. 526-540. Date of Electronic Publication: 2022 Jan 21.
DOI:	10.3390/cimb44020036
Abstrakt:	Extracellular vesicles, which are highly conserved in most cells, contain biologically active substances. The vesicles and substances interact with cells and impact physiological mechanisms. The skin is the most external organ and is in direct contact with the external environment. Photoaging and skin damage are caused by extrinsic factors. The formation of wrinkles is a major indicator of skin aging and is caused by a decrease in collagen and hyaluronic acid. MMP-1 expression is also increased. Due to accruing damage, skin aging reduces the ability of the skin barrier, thereby lowering the skin's ability to contain water and increasing the amount of water loss. L. plantarum suppresses various harmful bacteria by secreting an antimicrobial substance. L. plantarum is also found in the skin, and research on the interactions between the bacteria and the skin is in progress. Although several studies have investigated L. plantarum , there are only a limited number of studies on extracellular vesicles (EV) derived from L. plantarum , especially in relation to skin aging. Herein, we isolated EVs that were secreted from L. plantarum of women in their 20s ( Lp EVs). We then investigated the effect of Lp EVs on skin aging in CCD986sk. We showed that Lp EVs modulated the mRNA expression of ECM related genes in vitro. Furthermore, Lp EVs suppressed wrinkle formation and pigmentation in clinical trials. These results demonstrated that Lp EVs have a great effect on skin aging by regulating ECM related genes. In addition, our study offers important evidence on the depigmentation effect of Lp EVs.
Databáze:	MEDLINE
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