Gut microbiome: Linking together obesity, bariatric surgery and associated clinical outcomes under a single focus.

Autor:	Georgiou K; The First Propaedeutic Surgical Unit, Hippocrateion Athens General Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece., Belev NA; Medical Simulation Training Center, Research Institute of Medical University of Plovdiv, and UMPHAT 'Eurohospital', Medical University of Plovdiv, Plovdiv 4002, Bulgaria., Koutouratsas T; Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece., Katifelis H; Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece., Gazouli M; Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece. mgazouli@med.uoa.gr.
Jazyk:	angličtina
Zdroj:	World journal of gastrointestinal pathophysiology [World J Gastrointest Pathophysiol] 2022 May 22; Vol. 13 (3), pp. 59-72.
DOI:	10.4291/wjgp.v13.i3.59
Abstrakt:	Obesity is increasingly prevalent in the post-industrial era, with increased mortality rates. The gut microbiota has a central role in immunological, nutritional and metabolism mediated functions, and due to its multiplexity, it is considered an independent organ. Modern high-throughput sequencing techniques have allowed phylogenetic exploration and quantitative analyses of gut microbiome and improved our current understanding of the gut microbiota in health and disease. Its role in obesity and its changes following bariatric surgery have been highlighted in several studies. According to current literature, obesity is linked to a particular microbiota profile that grants the host an augmented potential for calorie release, while limited diversity of gut microbiome has also been observed. Moreover, bariatric surgery procedures represent effective interventions for sustained weight loss and restore a healthier microbiota, contributing to the observed fat mass reduction and lean mass increase. However, newer evidence has shown that gut microbiota is only partially recovered following bariatric surgery. Moreover, several targets including FGF15/19 (a gut-derived peptide), could be responsible for the favorable metabolic changes of bariatric surgery. More randomized controlled trials and larger prospective studies that include well-defined cohorts are required to better identify associations between gut microbiota, obesity, and bariatric surgery. Competing Interests: Conflict-of-interest statement: Authors declare no conflict of interests for this article. (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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