[Pre- and post-chemotherapy tumor volumes: New prognostic factors in nasopharyngeal carcinoma].

Autor: Mnejja W; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie., Nouri O; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie. Electronic address: omar.nouri1991@yahoo.com., Fourati N; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie., Trigui R; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie., Sahnoun T; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie., Siala W; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie., Charfeddine I; Service d'oto-rhino-laryngologie, CHU de Habib-Bourguiba, Sfax, Tunisie., Khanfir A; Service de carcinologie médicale, CHU de Habib-Bourguiba, Sfax, Tunisie., Farhat L; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie., Daoud J; Service de radiothérapie carcinologique, CHU de Habib-Bourguiba, Sfax, Tunisie.
Jazyk: francouzština
Zdroj: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2022 Sep; Vol. 26 (5), pp. 703-710. Date of Electronic Publication: 2022 Jun 15.
DOI: 10.1016/j.canrad.2022.01.005
Abstrakt: Purpose: The pre- and post-induction chemotherapy tumor volumes of nasopharyngeal carcinomas may be prognostic indicators for adapting the therapeutic strategy. The objective of our study is to assess the prognostic impact of pre- and post-induction chemotherapy volumes in patients treated for locally advanced nasopharyngeal carcinomas.
Patients and Methods: This is a retrospective study including 52 patients with locally advanced nasopharyngeal carcinoma treated with 3 courses of induction chemotherapy (TPF) followed by intensity modulated radiotherapy associated with concomitant chemotherapy.
Results: The median initial and post induction chemotherapy total volumes were 92.3 and 41.5mL, respectively. At 3 years, the LRFS, DMFS, DFS and OS were respectively 85.9%, 63.5%, 56.8% and 67.8%. In multivariate study, the combination of a high initial volume (>100mL) and post-chemotherapy volume (>35mL) was an independent factor for LRFS, DMFS, DFS and OS. The total baseline volume had a better predictive prognostic value for DFS and OS than the TNM classification (8th edition 2017).
Conclusion: The prognostic weight of tumor and nodal volumes was greater than the TNM classification (8th edition). The pre- and post-chemotherapy tumor volumes allow selecting a high-risk patients' subgroup "high initial and post chemotherapy volumes" in which it would be advisable to offer more intensive treatment regimens.
(Copyright © 2022 Société française de radiothérapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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