Effects of combined physical exercise on plasma lipid variables, paraoxonase 1 activity, and inflammation parameters in adults with obesity: a randomized clinical trial.

Autor: Streb AR; Grupo de Estudo e Pesquisa em Exercício Físico e Doenças Crônicas Não Transmissíveis, Centro de Desportos-CDS, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil. anne.streb@posgrad.ufsc.br., Braga PGS; Laboratório de Metabolismo e Lípides, Instituto do Coração, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, 05403-000, Brazil., de Melo RF; Departamento de Análises Clínicas, Centro de Ciências da Saúde-CCS, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil., Botelho LJ; Departamento de Saúde Pública, Centro de Ciências da Saúde-CCS, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil., Maranhão RC; Laboratório de Metabolismo e Lípides, Instituto do Coração, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, 05403-000, Brazil., Del Duca GF; Grupo de Estudo e Pesquisa em Exercício Físico e Doenças Crônicas Não Transmissíveis, Centro de Desportos-CDS, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil.
Jazyk: angličtina
Zdroj: Journal of endocrinological investigation [J Endocrinol Invest] 2022 Oct; Vol. 45 (10), pp. 1991-1997. Date of Electronic Publication: 2022 Jun 17.
DOI: 10.1007/s40618-022-01833-3
Abstrakt: Objective: We aimed to investigate whether combined physical exercise may affect plasma lipid variables, paraoxonase 1 (PON1) activity, and inflammation parameters in adults with obesity.
Methods: Thirty-six participants were recruited to complete the study protocol. The mean age was 37 ± 1 years, and the baseline body mass index was 33.0 ± 0.4 kg/m 2 . Participants were allocated to the control group (CG) and the exercise group (EG). The EG performed three weekly sessions of combined physical exercise for 16 weeks. Plasma lipid variables, PON1 activity, and inflammatory profile were determined before and after intervention.
Results: Total cholesterol levels decreased in both groups, without intergroup difference (time p = 0.001). Non-high-density lipoprotein cholesterol (HDL-C) levels decreased in both groups (time p = 0.001); however, they were lower in the EG than in the CG (p = 0.038). The EG had increased HDL-C levels, but the CG had decreased HDL-C levels (time*group p = 0.011). PON1 activity was reduced in both groups (time, p = 0.001). The Castelli risk Index I and II reduced in the EG and increased in the CG (time*group, p = 0.008 and p = 0.011, respectively). The inflammatory markers were not modified.
Conclusion: Adults with obesity may benefit from regular practice of combined physical exercise training in many metabolic aspects that are related to protection against the development of cardiovascular disease.
(© 2022. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).)
Databáze: MEDLINE
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