Pharmacological characterization of a novel putative nootropic beta-alanine derivative, MB-005, in adult zebrafish.

Autor:	Kolesnikova TO; Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia., Galstyan DS; Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia., Demin KA; Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia.; Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, Saint Petersburg, Russia., Barabanov MA; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia., Pestov AV; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russia.; Ural Federal University, Yekaterinburg, Russia., S de Abreu M; Moscow Institute of Physics and Technology, Moscow, Russia., Strekalova T; Maastricht University, Maastricht, The Netherlands.; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Department of Normal Physiology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.; Institute of General Pathology and Pathophysiology, Moscow, Russia., Kalueff AV; Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia.; Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia.; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, Saint Petersburg, Russia.; Moscow Institute of Physics and Technology, Moscow, Russia.; Maastricht University, Maastricht, The Netherlands.; COBRAIN Center, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.; Scientific Research Institute of Neurosciences and Medicine, Novosibirsk, Russia.; School of Pharmacy, Southwest University, Chongqing, China.
Jazyk:	angličtina
Zdroj:	Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2022 Jul; Vol. 36 (7), pp. 892-902. Date of Electronic Publication: 2022 Jun 17.
DOI:	10.1177/02698811221098192
Abstrakt:	Background: Cognitive deficits represent an urgent biomedical problem, and are commonly reduced by nootropic drugs. Animal models, including both rodents and zebrafish, offer a valuable tool for studying cognitive phenotypes and screening novel nootropics. Beta-alanine and its derivatives have recently been proposed to exert nootropic activity. Aims: This study aimed to characterize putative nootropic profile of a novel β-alanine analogue, 1,3-diaminopropane (MB-005), in adult zebrafish. Methods: Nootropic profile of MB-005 was assessed in adult zebrafish in the novel tank and conditioned place aversion (CPA) tests acutely, and in cued-learning plus-maze (PMT) tests chronically. Results/outcomes: MB-005 did not alter zebrafish anxiety-like behavior or monoamine neurochemistry acutely, improved short-term memory in the CPA test, but impaired cognitive performance in both CPA and PMT tests chronically. Conclusions/interpretation: This study reveals high sensitivity of zebrafish cognitive phenotypes to MB-005, suggesting it as a potential novel cognitive enhancer acutely, but raises concerns over its cognitive (and, possibly, other) side-effects chronically.
Databáze:	MEDLINE
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