Supplementation With Spirulina platensis Improves Tracheal Reactivity in Wistar Rats by Modulating Inflammation and Oxidative Stress.

Autor:	Brito AF; School of Physical Education, University of Pernambuco, Recife, Brazil.; Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil., Silva AS; Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil.; Physical Education Department, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., de Souza AA; Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil.; Federal University of Tocantins, Licentiate in Physical Education, Tocantinopolis, Brazil., Ferreira PB; Postgraduate Program in Natural and Synthetic Products Bioactive, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil., de Souza ILL; Department of Biological Sciences and Health, Roraima State University, Boa Vista, Brazil., Araujo LCDC; Department of Biophysics and Physiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., da Silva BA; Postgraduate Program in Natural and Synthetic Products Bioactive, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil.; Pharmaceutical Sciences Department, Health Sciences Center, Federal University of Paraiba, João Pessoa, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2022 May 31; Vol. 13, pp. 826649. Date of Electronic Publication: 2022 May 31 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.826649
Abstrakt:	Spirulina platensis has shown effectiveness in the treatment of allergic rhinitis in rats, but its action in tracheal reactivity or on markers of relaxation and antioxidant profile has not yet been possible to determine. In this paper, the animals were divided into the groups healthy (SG) and supplemented with S. platensis at doses of 50 (SG50), 150 (SG150), and 500 mg/kg (SG500). We also evaluated nitrite levels, lipid peroxidation, and antioxidant activity through biochemical analysis. For contractile reactivity, only SG500 (pEC50 = 5.2 ± 0.06 showed reduction in carbachol contractile potency. Indomethacin caused a higher contractile response to carbachol in SG150 and SG500. For relaxation, curves for SG150 (pEC50 = 5.0 ± 0.05) and SG500 (pEC50 = 7:3 ± 0:02) were shifted to the left, more so in SG500. We observed an increase in nitrite in the trachea only with supplementation of 500 mg/kg (54.0 ± 8.0 µM), also when compared to SG50 (37.0 ± 10.0 µM) and SG150 (38.0 ± 7.0 µM). We observed a decrease in lipid peroxidation in the plasma and an increase in oxidation inhibition for the trachea and lung in SG150 and SG500, suggesting enhanced antioxidant activity. S. platensis (150/500 mg/kg) decreased the contractile response and increased relaxation by increasing antioxidant activity and nitrite levels and modulating the inflammatory response. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Brito, Silva, de Souza, Ferreira, Souza, Araujo and da Silva.)
Databáze:	MEDLINE
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