Admission Levels of Serum P-Selectin and IL-6 Can Predict Development of Deep Venous Thrombosis in Hospitalized Covid-19 Patients.

Autor:	Farouk N; Vascular Surgery Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Ashry WMO; Microbiology and Immunology Department, Damietta Faculty of Medicine (Girls), Al-Azhar University, Damietta, Egypt., El-Hagrasy HA; Clinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Mohamed EF; Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Eltrawy HH; Chest Diseases Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., El-Nasser AM; Medical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Shipl W; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Attar SE; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Kh Sakr L; Radio-Diagnosis Department, faculty of medicine for girls, Al-Azhar University, Cairo, Egypt., Abdel Wahab MA; Vascular Surgery Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Abdelsalam EM; Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Sharaf FA; Clinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Ahmad IH; Endocrinology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	International journal of general medicine [Int J Gen Med] 2022 Jun 10; Vol. 15, pp. 5599-5607. Date of Electronic Publication: 2022 Jun 10 (Print Publication: 2022).
DOI:	10.2147/IJGM.S357097
Abstrakt:	Background and Aim: Deep venous thrombosis (DVT) of the lower extremities is common in Covid-19 patients. Interleukin (IL)-6 and P-selectin were found to be elevated in Covid-19 patients. The current study aimed to evaluate P-selectin and IL6 in Covid-19 patients with DVT and to explore its relation to clinical and laboratory parameters in those patients. Patients and Methods: The present retrospective study included 150 hospitalized COVID-19 patients diagnosed on the basis of a positive result of reverse-transcriptase polymerase chain reaction (RT-PCR) test. Laboratory assessments were included for IL-6 and P selectin assessments via enzyme-linked immunosorbent assay. The primary outcome of the present study was the development of DVT detected by Doppler ultrasound (DU) evaluation of the lower extremities during the admission. Results: The present study included 150 hospitalized Covid-19 patients. DVT was developed in 59 patients (39.3%). DVP patients had significantly higher levels of P selectin [76.0 (63.0-87.0) versus 63.0 (54.3-75.0), p < 0.001] and IL-6 [37.0 (27.0-49.0) versus 18.5 (13.5-31.5), p < 0.001]. ROC curve analysis revealed good performance of P selectin [AUC (95% CI): 0.72 (0.64-0.81)] and IL-6 [AUC (95% CI): 0.79 (0.71-0.86)] in identification of DVT. Logistic regression analysis identified the presence of severe disease [OR (95% CI): 9.016 (3.61-22.49), p < 0.001], elevated P selectin [OR (95% CI): 1.032 (1.005-1.059), p = 0.018] and elevated IL-6 [OR (95% CI): 1.062 (1.033-1.091), p < 0.001] as significant predictors of DVT development in multivariate analysis. Conclusion: The present study identified a probable role of elevated P-selectin and IL-6 levels in the DVT development in hospitalized Covid-19 patients. Competing Interests: The authors declare that they have no conflicts of interest in relation to this work. (© 2022 Farouk et al.)
Databáze:	MEDLINE
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