Cranial Morphology Associated With Syndromic Craniosynostosis: A Potential Detection of Abnormality in Patient's Cranial Growth Using Angular Statistics.

Autor:	Zulkipli NS; Centre for Mathematical Sciences, Universiti Malaysia Pahang, Kuantan, Pahang, Malaysia., Satari SZ; Centre for Mathematical Sciences, Universiti Malaysia Pahang, Kuantan, Pahang, Malaysia., Hariri F; Oro-Craniomaxillofacial Research and Surgical Group, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia., Abdullah NA; Mathematics Division, Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur, Malaysia., Wan Yusoff WNS; Centre for Mathematical Sciences, Universiti Malaysia Pahang, Kuantan, Pahang, Malaysia., Hussin AG; Centre for Defence Foundation Studies, National Defence University of Malaysia, Kuala Lumpur, Malaysia.
Jazyk:	angličtina
Zdroj:	The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association [Cleft Palate Craniofac J] 2023 Nov; Vol. 60 (11), pp. 1484-1493. Date of Electronic Publication: 2022 Jun 16.
DOI:	10.1177/10556656221107524
Abstrakt:	Introduction: Apert, Crouzon, and Pfeiffer syndromes are common genetic syndromes related to syndromic craniosynostosis (SC), whereby it is a congenital defect that occurs when the cranial growth is distorted. Identifying cranial angles associated with these 3 syndromes may assist the surgical team to focus on a specific cranial part during the intervention planning, thus optimizing surgical outcomes and reducing potential morbidity. Objective: The aim of this study is to identify the cranial angles, which are associated with Apert, Crouzon, and Pfeiffer syndromes. Methods: The cranial computed tomography scan images of 17 patients with SC and 22 control groups aged 0 to 12 years who were treated in the University Malaya Medical Centre were obtained, while 12 angular measurements were attained using the Mimics software. The angular data were then divided into 2 groups (patients aged 0 to 24 months and >24 months). This work proposes a 95% confidence interval (CI) for angular mean to detect the abnormality in patient's cranial growth for the SC syndromes. Results: The 95% CI of angular mean for the control group was calculated and used as an indicator to confirm the abnormality in patient's cranial growth that is associated with the 3 syndromes. The results showed that there are different cranial angles associated with these 3 syndromes. Conclusions: All cranial angles of the patients with these syndromes lie outside the 95% CI of angular mean of control group, indicating the reliability of the proposed CI in the identification of abnormality in the patient's cranial growth. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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