The Drosophila circadian clock circuit is a nonhierarchical network of peptidergic oscillators.

Autor: Crespo-Flores SL; Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers, the State University of New Jersey, USA., Barber AF; Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers, the State University of New Jersey, USA. Electronic address: annika.barber@waksman.rutgers.edu.
Jazyk: angličtina
Zdroj: Current opinion in insect science [Curr Opin Insect Sci] 2022 Aug; Vol. 52, pp. 100944. Date of Electronic Publication: 2022 Jun 13.
DOI: 10.1016/j.cois.2022.100944
Abstrakt: The relatively simple Drosophila circadian clock circuit consists of 150 clock neurons that coordinate rhythmic behavior and physiology, which are generally classified based on neuroanatomical location. Transcriptional and connectomic studies have identified novel subdivisions of these clock neuron populations, and identified neuropeptides not previously known to be expressed in the fly clock circuit. An additional feature of fly clock neurons is daily axonal remodeling, first noted in small ventrolateral neurons, but more recently also found in additional clock neuron groups. These findings raise new questions about the functional roles of clock neuron subpopulations and daily remodeling of network architecture in regulating circadian behavior and physiology.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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