Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment.

Autor:	Jang HJ; Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Lee HS; Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Yu W; Department of Pathology/Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ramineni M; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas., Truong CY; Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Ramos D; Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Splawn T; Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Choi JM; Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Jung SY; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas., Lee JS; Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wang DY; Division of Hemato-Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas., Sederstrom JM; Advanced Technology Cores, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas., Pietropaolo M; Division of Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, Texas., Kheradmand F; Division of Pulmonology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey Department of Veterans Affairs, Houston, Texas., Amos CI, Wheeler TM, Ripley RT, Burt BM; Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.
Jazyk:	angličtina
Zdroj:	Cancer research [Cancer Res] 2022 Jul 18; Vol. 82 (14), pp. 2593-2609.
DOI:	10.1158/0008-5472.CAN-21-3506
Abstrakt:	Significance: Comprehensive single-cell proteomics analyses of lung adenocarcinoma progression reveal the role of tumor-associated macrophages in resistance to PD-1 blockade therapy. See related commentary by Lee et al., p. 2515. (©2022 American Association for Cancer Research.)
Databáze:	MEDLINE
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