Association of obstructive sleep apnea with thyroid cancer incidence: a systematic review and meta-analysis.

Autor: Tan BKJ; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Tan NKW; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Teo YH; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Yap DWT; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Raghupathy J; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Gao EY; Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Toh ST; Department of Otorhinolaryngology-Head and Neck Surgery, Singapore General Hospital (SGH), Outram Road, Singapore, 169608, Singapore.; Surgery Academic Clinical Program, SingHealth, Singapore, Singapore., See A; Department of Otorhinolaryngology-Head and Neck Surgery, Singapore General Hospital (SGH), Outram Road, Singapore, 169608, Singapore. anna.see.xinyin@singhealth.com.sg.; Surgery Academic Clinical Program, SingHealth, Singapore, Singapore. anna.see.xinyin@singhealth.com.sg.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2022 Nov; Vol. 279 (11), pp. 5407-5414. Date of Electronic Publication: 2022 Jun 16.
DOI: 10.1007/s00405-022-07457-w
Abstrakt: Purpose: Obstructive sleep apnea (OSA) is a postulated carcinogen based on epidemiological associations with all-cancer incidence and non-thyroid biological models. However, associations with thyroid carcinoma are unclear.
Methods: We included observational/randomized studies of associations of OSA with thyroid carcinoma incidence/mortality in adults, from four databases. Random-effects meta-analyses and the population attributable fraction (PAF; from published global OSA prevalence estimates) were computed.
Results: We included four observational studies (N = 2,839,325), all with moderate/low risk of bias. OSA diagnosis was associated with twofold incidence of thyroid carcinoma (pooled HR 2.32, 95% CI 1.35-3.98, I 2  = 95%), after multi-adjustment for demographics, BMI, smoking, alcohol, and comorbidities. Subgroup analysis of studies with at least 5 years of follow-up showed a stronger association of OSA with thyroid cancer incidence (pooled HR 3.27, 95% CI 2.80-3.82, I 2  = 0%). Up to 14.5% (95% CI 4.29-27.6%) of incident thyroid carcinomas globally may be associated with OSA. Thyroid carcinoma mortality data was unavailable.
Conclusions: OSA is associated with higher thyroid carcinoma incidence, though this does not prove causation. Biological/clinical studies should investigate OSA severity in relation to thyroid carcinoma progression and mortality, stratified by tumor histology.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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