A comparative study of sedo-analgesic effect of dexmedetomidine and dexmedetomidine with ketamine in postoperative mechanically ventilated patients.

Autor: Gupta BK; Department of Anaesthesiology, IMS, BHU, Varanasi, Uttar Pradesh, India., Mhaske VR; Department of Obstetrics and Gynaecology, IMS, BHU, Varanasi, Uttar Pradesh, India., Pai VK; Speciality Registrar, Department of Anaesthesiology, North Devon District Hospital, Barnstaple, Devon, England., Mishra LD; Department of Anaesthesiology, IMS, BHU, Varanasi, Uttar Pradesh, India.
Jazyk: angličtina
Zdroj: Journal of anaesthesiology, clinical pharmacology [J Anaesthesiol Clin Pharmacol] 2022 Jan-Mar; Vol. 38 (1), pp. 68-72. Date of Electronic Publication: 2022 Feb 03.
DOI: 10.4103/joacp.JOACP_234_19
Abstrakt: Background and Aims: To compare the sedoanalgesic effects of dexmedetomidine alone or with combination of ketamine.
Material and Methods: After getting ethical approval and informed patient consent, 60 adult surgical patients, were randomly divided into two groups. Group KD ( n = 30); received dexmedotomidine 0.5 μg/kg/h mixed with ketamine 0.5 μg/kg/h and Group DEX ( n = 30); received dexmedotomidine at 0.5 mg/kg/h infusion only. In both the groups, study drugs were titrated (dexmedetomidine- 0.2-0.7 μg/kg/h and ketamine 0.2-0.7 mg/kg/h) to achieve target sedation. Hemodynamic variables, pain scores, sedation scores, and patient satisfaction were recorded. Qualitative and Quantitative data were analyzed with Pearson Chi-squared test and analysis of variance test, respectively. All analyses were done by using statistical package for social sciences (SPSS) version 16.0.
Results: Pain scores were higher in group DEX than in group KD at 2 h and 4 h which was statistically significant ( P < 0.05). At the end of 2 h, sedation scores were higher in group KD than in group DEX and was statistically significant ( P < 0.05). Length of intensive care unit stay was almost comparable in both groups, and the time to tracheal extubation was lesser in ketamine-dexmedetomidine group as compared to the dexmedetomidine alone group. However the difference was statistically non-significant.
Conclusions: By combining dexmedetomidine with ketamine we observed lower incidence of hypotension and bradycardia. Dexmedetomidine with ketamine combination therapy could be used safely and effectively as sedo-analgesic agent.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Journal of Anaesthesiology Clinical Pharmacology.)
Databáze: MEDLINE
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