Effect of CYP2C9 , PTGS-1 and PTGS-2 gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen.
| Autor: | Sychev DA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Morozova TE; Department of Clinical Pharmacology and Internal Diseases, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Shatskiy DA; Department of Clinical Pharmacology and Internal Diseases, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Shikh NV; Department of Clinical Pharmacology and Internal Diseases, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Shikh EV; Department of Clinical Pharmacology and Internal Diseases, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Andrushchyshina TB; Department of Clinical Pharmacology and Internal Diseases, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Lukina MV; Department of Clinical Pharmacology and Internal Diseases, Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation., Kachanova AA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Sozaeva ZA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Abdullaev SP; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Denisenko NP; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation., Ryzhikova KA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation. |
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| Jazyk: | angličtina |
| Zdroj: | Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2022 Jun 15; Vol. 37 (4), pp. 361-368. Date of Electronic Publication: 2022 Jun 15 (Print Publication: 2022). |
| DOI: | 10.1515/dmpt-2021-0222 |
| Abstrakt: | Objectives: Patients undergoing cardiac surgery develop post-sternotomy pain syndrome. The aim of this study was evaluation of the influence of CYP2C9 , PTGS-1 and PTGS-2 genes polymorphisms on the efficacy and safety of postoperative analgesia with ketoprofen in patients with coronary artery disease after cardiac surgery. Methods: The study included 90 patients undergoing cardiac surgery. A real-time polymerase chain reaction was used for the detection of single nucleotide polymorphisms (SNP). Pain intensity was measured by the Numeric Rating Scale (NRS). Dyspeptic symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS). Acute kidney injury (AKI) was determined by Kidney Disease Improving Global Outcomes criteria. Results: Pain intensity by the NRS score was significantly higher in patients with CYP2C9*3 АA genotype compared to АC genotype: 7 [1,10] and 6 [2,7] (p=0.003); 7 [1,10] and 6 [2,7] (p=0.04); 6 [0; 10] and 5 [2,6] (p=0.04); 5 [0; 8] and 3 [0; 8] (p=0.02), on days 1, 2, 3 and 5 in the postoperative period, respectively. GSRS score was higher in patients with CYP2C9*2 CT genotype compared to CС genotype: 19 [15; 42] and 18 [15,36] (p=0.04), respectively. There were no significant differences in the pain intensity, dyspepsia severity and AKI frequency in patients with homozygous and heterozygous genotypes for PTGS-1 rs10306135, PTGS-1 rs12353214, PTGS-2 rs20417. Conclusions: CYP2C9*3 and CYP2C9*2 gene polymorphisms may affect efficacy and safety of postoperative analgesia with ketoprofen in patients with coronary artery disease after cardiac surgery. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.) |
| Databáze: | MEDLINE |
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