MXene-Assisted Ablation of Cells with a Pulsed Near-Infrared Laser.

Autor: Kyrylenko S; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine., Gogotsi O; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine., Baginskiy I; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine., Balitskyi V; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine., Zahorodna V; Materials Research Centre, 3 Krzhizhanovskogo Street, Kyiv 03680, Ukraine., Husak Y; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.; Silesian University of Technology, 2A Akademicka Street, Gliwice 44-100, Poland., Yanko I; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine., Pernakov M; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine., Roshchupkin A; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine., Lyndin M; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine., Singer BB; Institute of Anatomy, Medical Faculty, University Duisburg-Essen, 171 Virchowstraße, Essen 45147, Germany., Buranych V; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine., Pogrebnjak A; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.; Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan., Sulaieva O; Medical Laboratory CSD, 45 Vasylkivska Street, Kyiv 02000, Ukraine., Solodovnyk O; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.; VERBA MEDICAL LTD, 31A Lushpy Street, Sumy 40035, Ukraine., Gogotsi Y; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.; Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, United States., Pogorielov M; Sumy State University, 31 Sanatorna Street, Sumy 40007, Ukraine.; University of Latvia, Institute of Atomic Physics and Spectroscopy, 3 Jelgavas Street, Riga LV-1004, Latvia.
Jazyk: angličtina
Zdroj: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2022 Jun 29; Vol. 14 (25), pp. 28683-28696. Date of Electronic Publication: 2022 Jun 15.
DOI: 10.1021/acsami.2c08678
Abstrakt: Innovative therapies are urgently needed to combat cancer. Thermal ablation of tumor cells is a promising minimally invasive treatment option. Infrared light can penetrate human tissues and reach superficial malignancies. MXenes are a class of 2D materials that consist of carbides/nitrides of transition metals. The transverse surface plasmons of MXenes allow for efficient light absorption and light-to-heat conversion, making MXenes promising agents for photothermal therapy (PTT). To date, near-infrared (NIR) light lasers have been used in PTT studies explicitly in a continuous mode. We hypothesized that pulsed NIR lasers have certain advantages for the development of tailored PTT treatment targeting tumor cells. The pulsed lasers offer a wide range of controllable parameters, such as power density, duration of pulses, pulse frequency, and so on. Consequently, they can lower the total energy applied and enable the ablation of tumor cells while sparing adjacent healthy tissues. We show for the first time that a pulsed 1064 nm laser could be employed for selective ablation of cells loaded with Ti 3 C 2 T x MXene. We demonstrate both low toxicity and good biocompatibility of this MXene in vitro , as well as a favorable safety profile based on the experiments in vivo . Furthermore, we analyze the interaction of MXene with cells in several cell lines and discuss possible artifacts of commonly used cellular metabolic assays in experiments with MXenes. Overall, these studies provide a basis for the development of efficient and safe protocols for minimally invasive therapies for certain tumors.
Databáze: MEDLINE