Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia.

Autor:	Cutts JC; Burnet Institute, Melbourne, Victoria, Australia.; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., O'Flaherty K; Burnet Institute, Melbourne, Victoria, Australia., Zaloumis SG; Centre for Epidemiology and Biostatistics, Melbourne, School of Population and Global Health, University of Melbourne, Melbourne, Australia., Ashley EA; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Lao-Oxford-Mahosot Hospital-Wellcome Trust-Research Unit, Mahosot Hospital, Vientiane, Lao PDR., Chan JA; Burnet Institute, Melbourne, Victoria, Australia.; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Immunology, Monash University, Melbourne, Australia., Onyamboko MA; Kinshasa School of Public Health, Kinshasa, Democratic Republic of Congo., Fanello C; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Kinshasa School of Public Health, Kinshasa, Democratic Republic of Congo., Dondorp AM; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom., Day NP; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom., Phyo AP; Myanmar Oxford Clinical Research Unit, Yangon, Myanmar., Dhorda M; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; WorldWide Antimalarial Resistance Network, Asia-Pacific Regional Centre, Bangkok, Thailand., Imwong M; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Fairhurst RM; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA., Lim P; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA., Amaratunga C; WorldWide Antimalarial Resistance Network, Asia-Pacific Regional Centre, Bangkok, Thailand., Pukrittayakamee S; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Hien TT; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Htut Y; Department of Medical Research, Ministry of Health and Sports, Yangon, Myanmar., Mayxay M; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Lao-Oxford-Mahosot Hospital-Wellcome Trust-Research Unit, Mahosot Hospital, Vientiane, Lao PDR.; Institute of Research and Education Development, University of Health Sciences, Vientiane, Lao PDR., Faiz MA; Malaria Research Group & Dev Care Foundation, Chittagong, Bangladesh., Takashima E; Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan., Tsuboi T; Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan., Beeson JG; Burnet Institute, Melbourne, Victoria, Australia.; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Immunology, Monash University, Melbourne, Australia., Nosten F; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.; Shoklo Malaria Research Unit, Mae Sot, Thailand., Simpson JA; Centre for Epidemiology and Biostatistics, Melbourne, School of Population and Global Health, University of Melbourne, Melbourne, Australia., White NJ; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom., Fowkes FJI; Burnet Institute, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne, School of Population and Global Health, University of Melbourne, Melbourne, Australia.; Department of Infectious Diseases and Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Australia.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Aug 24; Vol. 226 (2), pp. 324-331.
DOI:	10.1093/infdis/jiac232
Abstrakt:	Background: Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southeast Asia, where resistance has emerged, P. falciparum antibodies confound parasite clearance measures. However, variation in naturally acquired antibodies across Asian and sub-Saharan African epidemiological contexts and their impact on parasite clearance re yet to be quantified. Methods: In an artemisinin therapeutic efficacy study, antibodies to 12 pre-erythrocytic and erythrocytic P. falciparum antigens were measured in 118 children with uncomplicated P. falciparum malaria in the Democratic Republic of Congo (DRC) and compared with responses in patients from Asian sites, described elsewhere. Results: Parasite clearance half-life was shorter in DRC patients (median, 2 hours) compared with most Asian sites (median, 2-7 hours), but P. falciparum antibody levels and seroprevalences were similar. There was no evidence for an association between antibody seropositivity and parasite clearance half-life (mean difference between seronegative and seropositive, -0.14 to +0.40 hour) in DRC patients. Conclusions: In DRC, where artemisinin remains highly effective, the substantially shorter parasite clearance time compared with Asia was not explained by differences in the P. falciparum antibody responses studied. (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu