Prenatal exposure to multiple organochlorine compounds and childhood body mass index.

Autor:	Colicino E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York., Margetaki K; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Valvi D; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York., Pedretti NF; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York., Stratakis N; ISGlobal, Barcelona, Spain., Vafeiadi M; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Roumeliotaki T; Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece., Kyrtopoulos SA; Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece., Kiviranta H; Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland., Stephanou EG; Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Heraklion, Greece., Kogevinas M; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Barcelona, Spain., McConnell R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Berhane KT; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York., Chatzi L; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Conti DV; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York.
Jazyk:	angličtina
Zdroj:	Environmental epidemiology (Philadelphia, Pa.) [Environ Epidemiol] 2022 Apr 22; Vol. 6 (3), pp. e201. Date of Electronic Publication: 2022 Apr 22 (Print Publication: 2022).
DOI:	10.1097/EE9.0000000000000201
Abstrakt:	Background: Prenatal exposure to organochlorine compounds (OCs) has been associated with increased childhood body mass index (BMI); however, only a few studies have focused on longitudinal BMI trajectories, and none of them used multiple exposure mixture approaches. Aim: To determine the association between in-utero exposure to eight OCs and childhood BMI measures (BMI and BMI z-score) at 4 years and their yearly change across 4-12 years of age in 279 Rhea child-mother dyads. Methods: We applied three approaches: (1) linear mixed-effect regressions (LMR) to associate individual compounds with BMI measures; (2) Bayesian weighted quantile sum regressions (BWQSR) to provide an overall OC mixture association with BMI measures; and (3)Bayesian varying coefficient kernel machine regressions (BVCKMR) to model nonlinear and nonadditive associations. Results: In the LMR, yearly change of BMI measures was consistently associated with a quartile increase in hexachlorobenzene (HCB) (estimate [95% Confidence or Credible interval] BMI: 0.10 [0.06, 0.14]; BMI z-score: 0.02 [0.01, 0.04]). BWQSR results showed that a quartile increase in mixture concentrations was associated with yearly increase of BMI measures (BMI: 0.10 [0.01, 0.18]; BMI z-score: 0.03 [0.003, 0.06]). In the BVCKMR, a quartile increase in dichlorodiphenyldichloroethylene concentrations was associated with higher BMI measures at 4 years (BMI: 0.33 [0.24, 0.43]; BMI z-score: 0.19 [0.15, 0.24]); whereas a quartile increase in HCB and polychlorinated biphenyls (PCB)-118 levels was positively associated with BMI measures yearly change (BMI: HCB:0.10 [0.07, 0.13], PCB-118:0.08 [0.04, 012]; BMI z-score: HCB:0.03 [0.02, 0.05], PCB-118:0.02 [0.002,04]). BVCKMR suggested that PCBs had nonlinear relationships with BMI measures, and HCB interacted with other compounds. Conclusions: All analyses consistently demonstrated detrimental associations between prenatal OC exposures and childhood BMI measures. Competing Interests: The authors declare that they have no conflicts of interest with regard to the content of this report. (Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu