Clinical evidence for synergy between immunotherapy and radiotherapy (SITAR).

Autor: Gill S; Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; University of Western Australia, Crawley, Western Australia, Australia., Nowak AK; Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; University of Western Australia, Crawley, Western Australia, Australia.; Institute for Respiratory Health, Nedlands, Western Australia, Australia., Bowyer S; Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; University of Western Australia, Crawley, Western Australia, Australia., Endersby R; University of Western Australia, Crawley, Western Australia, Australia.; Telethon Kids Institute, Nedlands, Western Australia, Australia., Ebert MA; Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; University of Western Australia, Crawley, Western Australia, Australia., Cook A; University of Western Australia, Crawley, Western Australia, Australia.; Institute for Respiratory Health, Nedlands, Western Australia, Australia.
Jazyk: angličtina
Zdroj: Journal of medical imaging and radiation oncology [J Med Imaging Radiat Oncol] 2022 Sep; Vol. 66 (6), pp. 881-895. Date of Electronic Publication: 2022 Jun 14.
DOI: 10.1111/1754-9485.13441
Abstrakt: Previous preclinical and clinical trials have shown promising antitumour activity and toxicity profile when employing the 'Synergy between Immunotherapy and Radiotherapy' (SITAR) strategy. Approximately, one in seven radiation therapy studies currently recruiting is investigating SITAR. This article reviews the range of cancers known to respond to immunotherapy and publications analysing SITAR. It sets the background for work that needs to be done in future clinical trials. It also reviews the potential toxicities of immunotherapy and discusses areas where caution is required when combining treatments.
(© 2022 The Authors. Journal of Medical Imaging and Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Radiologists.)
Databáze: MEDLINE
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