Developmental Programming in Animal Models: Critical Evidence of Current Environmental Negative Changes.

Autor: Ramírez V; Departamento de Cirugía Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de Mexico, México., Bautista RJ; Servicio de Bioterio Y Cirugía Experimental, Facultad Mexicana de Medicina, Universidad La Salle, Ciudad de Mexico, México., Frausto-González O; Departamento de Biología de La Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, 14080, Ciudad de Mexico, México., Rodríguez-Peña N; Unidad de Biotecnología y Prototipos (UBIPRO), FES Iztacala, UNAM, Tlalnepantla, Estado de México, México., Betancourt ET; Servicio de Bioterio Y Cirugía Experimental, Facultad Mexicana de Medicina, Universidad La Salle, Ciudad de Mexico, México., Bautista CJ; Departamento de Biología de La Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI, Tlalpan, 14080, Ciudad de Mexico, México. bautistacarbajal@yahoo.com.mx.
Jazyk: angličtina
Zdroj: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2023 Feb; Vol. 30 (2), pp. 442-463. Date of Electronic Publication: 2022 Jun 13.
DOI: 10.1007/s43032-022-00999-8
Abstrakt: The Developmental Origins of Health and Disease (DOHaD) approach answers questions surrounding the early events suffered by the mother during reproductive stages that can either partially or permanently influence the developmental programming of children, predisposing them to be either healthy or exhibit negative health outcomes in adulthood. Globally, vulnerable populations tend to present high obesity rates, including among school-age children and women of reproductive age. In addition, adults suffer from high rates of diabetes, hypertension, cardiovascular, and other metabolic diseases. The increase in metabolic outcomes has been associated with the combination of maternal womb conditions and adult lifestyle-related factors such as malnutrition and obesity, smoking habits, and alcoholism. However, to date, "new environmental changes" have recently been considered negative factors of development, such as maternal sedentary lifestyle, lack of maternal attachment during lactation, overcrowding, smog, overurbanization, industrialization, noise pollution, and psychosocial stress experienced during the current SARS-CoV-2 pandemic. Therefore, it is important to recognize how all these factors impact offspring development during pregnancy and lactation, a period in which the subject cannot protect itself from these mechanisms. This review aims to introduce the importance of studying DOHaD, discuss classical programming studies, and address the importance of studying new emerging programming mechanisms, known as actual lifestyle factors, during pregnancy and lactation.
(© 2022. Society for Reproductive Investigation.)
Databáze: MEDLINE
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