Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.

Autor: Nelson PT; University of Kentucky, Rm 311 Sanders-Brown Center on Aging, Lexington, KY, USA. pnels2@email.uky.edu., Brayne C; University of Cambridge, Cambridge, UK., Flanagan ME; Northwestern University Medical Center, Chicago, IL, USA., Abner EL; University of Kentucky, Rm 311 Sanders-Brown Center on Aging, Lexington, KY, USA., Agrawal S; Rush University Medical Center, Chicago, IL, USA., Attems J; Newcastle University, Newcastle upon Tyne, UK., Castellani RJ; Northwestern University Medical Center, Chicago, IL, USA., Corrada MM; University of California, Irvine, CA, USA., Cykowski MD; Houston Methodist Hospital, Houston, TX, USA., Di J; University of Kentucky, Rm 311 Sanders-Brown Center on Aging, Lexington, KY, USA., Dickson DW; Mayo Clinic, Jacksonville, FL, USA., Dugger BN; University of California, Davis, CA, USA., Ervin JF; Duke University, Durham, NC, USA., Fleming J; University of Cambridge, Cambridge, UK., Graff-Radford J; Mayo Clinic, Rochester, MN, USA., Grinberg LT; University of California, San Francisco, CA, USA.; University of Sao Paulo Medical School, Sao Paulo, Brazil., Hokkanen SRK; University of Cambridge, Cambridge, UK., Hunter S; University of Cambridge, Cambridge, UK., Kapasi A; Rush University Medical Center, Chicago, IL, USA., Kawas CH; University of California, Irvine, CA, USA., Keage HAD; University of South Australia, Adelaide, SA, Australia., Keene CD; University of Washington, Seattle, WA, USA., Kero M; University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Knopman DS; Mayo Clinic, Rochester, MN, USA., Kouri N; Mayo Clinic, Jacksonville, FL, USA., Kovacs GG; Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.; Institute of Neurology, Medical University of Vienna, Vienna, Austria., Labuzan SA; Mayo Clinic, Jacksonville, FL, USA., Larson EB; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Latimer CS; University of Washington, Seattle, WA, USA., Leite REP; University of Sao Paulo Medical School, Sao Paulo, Brazil., Matchett BJ; Mayo Clinic, Jacksonville, FL, USA., Matthews FE; Newcastle University, Newcastle upon Tyne, UK., Merrick R; University of Cambridge, Cambridge, UK., Montine TJ; Stanford University, Stanford, CA, USA., Murray ME; Mayo Clinic, Jacksonville, FL, USA., Myllykangas L; University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Nag S; Rush University Medical Center, Chicago, IL, USA., Nelson RS; Emory University, Atlanta, GA, USA., Neltner JH; University of Kentucky, Rm 311 Sanders-Brown Center on Aging, Lexington, KY, USA., Nguyen AT; Mayo Clinic, Rochester, MN, USA., Petersen RC; Mayo Clinic, Rochester, MN, USA., Polvikoski T; Newcastle University, Newcastle upon Tyne, UK., Reichard RR; Mayo Clinic, Rochester, MN, USA., Rodriguez RD; University of Sao Paulo Medical School, Sao Paulo, Brazil., Suemoto CK; University of Sao Paulo Medical School, Sao Paulo, Brazil., Wang SJ; Duke University, Durham, NC, USA., Wharton SB; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., White L; Pacific Health Research and Education Institute, Honolulu, HI, USA., Schneider JA; Rush University Medical Center, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: Acta neuropathologica [Acta Neuropathol] 2022 Jul; Vol. 144 (1), pp. 27-44. Date of Electronic Publication: 2022 Jun 13.
DOI: 10.1007/s00401-022-02444-1
Abstrakt: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with substantial cognitive impairment in aging populations. However, the prevalence of LATE-NC across the full range of ADNC remains uncertain. To address this knowledge gap, neuropathologic, genetic, and clinical data were compiled from 13 high-quality community- and population-based longitudinal studies. Participants were recruited from United States (8 cohorts, including one focusing on Japanese-American men), United Kingdom (2 cohorts), Brazil, Austria, and Finland. The total number of participants included was 6196, and the average age of death was 88.1 years. Not all data were available on each individual and there were differences between the cohorts in study designs and the amount of missing data. Among those with known cognitive status before death (n = 5665), 43.0% were cognitively normal, 14.9% had MCI, and 42.4% had dementia-broadly consistent with epidemiologic data in this age group. Approximately 99% of participants (n = 6125) had available CERAD neuritic amyloid plaque score data. In this subsample, 39.4% had autopsy-confirmed LATE-NC of any stage. Among brains with "frequent" neuritic amyloid plaques, 54.9% had comorbid LATE-NC, whereas in brains with no detected neuritic amyloid plaques, 27.0% had LATE-NC. Data on LATE-NC stages were available for 3803 participants, of which 25% had LATE-NC stage > 1 (associated with cognitive impairment). In the subset of individuals with Thal Aβ phase = 0 (lacking detectable Aβ plaques), the brains with LATE-NC had relatively more severe primary age-related tauopathy (PART). A total of 3267 participants had available clinical data relevant to frontotemporal dementia (FTD), and none were given the clinical diagnosis of definite FTD nor the pathological diagnosis of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). In the 10 cohorts with detailed neurocognitive assessments proximal to death, cognition tended to be worse with LATE-NC across the full spectrum of ADNC severity. This study provided a credible estimate of the current prevalence of LATE-NC in advanced age. LATE-NC was seen in almost 40% of participants and often, but not always, coexisted with Alzheimer's disease neuropathology.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: