PD-L1 Overexpression in the Lungs of Subjects Who Died from COVID-19: Are We on the Way to Understanding the Immune System Exhaustion Induced by SARS-CoV-2?

Autor:	Ronchi A; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'Luigi Vanvitelli,' Naples, Italy., Marino FZ; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'Luigi Vanvitelli,' Naples, Italy., Carraturo E; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'Luigi Vanvitelli,' Naples, Italy., La Mantia E; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'Luigi Vanvitelli,' Naples, Italy., Campobasso CP; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli,' Naples, Italy., De Micco F; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Mascolo P; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli,' Naples, Italy., Municinò M; Forensic Medicine Unit, 'S. Giuliano' Hospital, Giugliano in Campania, Italy., Mucininò E; Forensic Medicine Unit, 'S. Giuliano' Hospital, Giugliano in Campania, Italy., Vestini F; Forensic Medicine Unit, 'S. Giuliano' Hospital, Giugliano in Campania, Italy., Pinto O; Forensic Medicine Unit, 'S. Giuliano' Hospital, Giugliano in Campania, Italy., Moccia M; Forensic Medicine Unit, 'S. Giuliano' Hospital, Giugliano in Campania, Italy., De Stefano N; Pathology Unit, 'San Giuseppe Moscati' Hospital, Avellino, Italy., Nappi O; Istituto Diagnostico 'Varelli,' Naples, Italy., Sementa C; Forensic Medicine Unit, AORN 'San Giuseppe Moscati,' Contrada Amoretta, 83100 Avellino, Italy., Zotti G; Forensic Medicine Unit, ASL Salerno, Italy., Pianese L; Forensic Medicine Unit, ASL Avellino, Italy., Giordano C; Forensic Medicine Unit, UOPC ASL NA3sud, Naples, Italy., Fico A; AMES, Centro Polidiagnostico Strumentale, Srl, Naples, Italy., Franco R; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania 'L Vanvitelli', Naples, Italy.
Jazyk:	angličtina
Zdroj:	Critical reviews in eukaryotic gene expression [Crit Rev Eukaryot Gene Expr] 2022; Vol. 32 (3), pp. 9-20.
DOI:	10.1615/CritRevEukaryotGeneExpr.2021040575
Abstrakt:	Knowledge of the pathogenic mechanisms of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) is certainly a priority for the scientific community. Two main elements are involved in the biology of the most severe forms of coronavirus disease 2019 (COVID-19): the direct cytopathic effect of the virus against the host tissues, and a dysfunction of the immune system, characterized by the exhaustion of T lymphocytes. The exhaustion of T cells in COVID-19 is poorly understand, but some data could suggest a possible role of PD-1/PD-L1 axis. The aim of this study was to evaluate the possible role of PD-L1 expression in the pulmonary tissue in subjects affected by COVID-19. The presence of SARS-CoV-2 in the pulmonary tissue, and its exact location, was indagated by in situ hybridization; the expression of PD-L1 and CD8 in the same tissue was indagated by immunohistochemistry. Overall, PD-L1 resulted diffusely expressed in 70% of the cases, and an intense expression was observed in 43.5% of cases. Diffuse and intense presence of SARS-CoV-2 by in situ hybridization significantly correlated with an intense PD-L1 expression, and with expression of PD-L1 by pneumocytes. PD-L1 is overexpressed in the pulmonary tissue of subjects died from COVID-19, and mainly in subjects with a high viral load. These data suggest a possible role of PD-L1 in the immune system exhaustion at the basis of the severe forms of the disease.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu