Hyper-Sensitivity to Pitch and Poorer Prosody Processing in Adults With Autism: An ERP Study.

Autor:	Haigh SM; Department of Psychology and Institute for Neuroscience, University of Nevada, Reno, NV, United States.; Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, United States., Brosseau P; Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, United States., Eack SM; School of Social Work, University of Pittsburgh, Pittsburgh, PA, United States., Leitman DI; Division of Translational Research, National Institute of Mental Health, Bethesda, MD, United States., Salisbury DF; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Behrmann M; Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2022 May 25; Vol. 13, pp. 844830. Date of Electronic Publication: 2022 May 25 (Print Publication: 2022).
DOI:	10.3389/fpsyt.2022.844830
Abstrakt:	Individuals with autism typically experience a range of symptoms, including abnormal sensory sensitivities. However, there are conflicting reports on the sensory profiles that characterize the sensory experience in autism that often depend on the type of stimulus. Here, we examine early auditory processing to simple changes in pitch and later auditory processing of more complex emotional utterances. We measured electroencephalography in 24 adults with autism and 28 controls. First, tones (1046.5Hz/C6, 1108.7Hz/C#6, or 1244.5Hz/D#6) were repeated three times or nine times before the pitch changed. Second, utterances of delight or frustration were repeated three or six times before the emotion changed. In response to the simple pitched tones, the autism group exhibited larger mismatch negativity (MMN) after nine standards compared to controls and produced greater trial-to-trial variability (TTV). In response to the prosodic utterances, the autism group showed smaller P3 responses when delight changed to frustration compared to controls. There was no significant correlation between ERPs to pitch and ERPs to prosody. Together, this suggests that early auditory processing is hyper-sensitive in autism whereas later processing of prosodic information is hypo-sensitive. The impact the different sensory profiles have on perceptual experience in autism may be key to identifying behavioral treatments to reduce symptoms. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Haigh, Brosseau, Eack, Leitman, Salisbury and Behrmann.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu