Influence of statin treatment in a cohort of patients admitted for COVID-19.

Autor: Rey JR; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Merino Llorens JL; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Iniesta Manjavacas ÁM; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Rosillo Rodríguez SO; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Castrejón-Castrejón S; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Arbas-Redondo E; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Poveda-Pinedo ID; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Tebar-Márquez D; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Severo-Sánchez A; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Rivero-Santana B; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Juárez-Olmos V; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Martínez-Cossiani M; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Buño-Soto A; Servicio de Análisis Clínicos, Hospital Universitario La Paz, Madrid, Spain., Gonzalez-Valle L; Servicio de Farmacia Hospitalaria, Hospital Universitario La Paz, Madrid, Spain., Herrero-Ambrosio A; Servicio de Farmacia Hospitalaria, Hospital Universitario La Paz, Madrid, Spain., López-de-Sá E; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain., Caro-Codón J; Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
Jazyk: angličtina
Zdroj: Medicina clinica (English ed.) [Med Clin (Engl Ed)] 2022 Jun 24; Vol. 158 (12), pp. 586-595. Date of Electronic Publication: 2022 Jun 03.
DOI: 10.1016/j.medcle.2022.05.004
Abstrakt: Aims and Objectives: Statins have been proposed as potentially useful agents for modulating the host response in COVID-19. However, solid evidence-based recommendations are still lacking. Our aim was to study the association between statin use and clinical outcomes in a large cohort of hospitalized patients with SARS-CoV-2 infection, as well as the specific consequences of chronic treatment withdrawal during hospital admission.
Material and Methods: Retrospective observational study including 2191 hospitalized patients with confirmed SARS-CoV-2 infection.
Results: Mean age was 68.0±17.8 years and 597 (27.3%) patients died during follow-up. A total of 827 patients (37.7% of the whole sample), received chronic treatment with statins. Even though they underwent more frequent admissions in critical care units, chronic treatment with statins was not independently associated with all-cause mortality [HR 0.95 (0.72-1.25)]. During the whole hospital admission, 371 patients (16.9%) received at least one dose of statin. Although these patients had a significantly worse clinical profile, both treatment with statins during admission [HR 1.03 (0.78-1.35)] and withdrawal of chronic statin treatment [HR 1.01 (0.78-1.30)] showed a neutral effect in mortality. However, patients treated with statins presented more frequently hepatic cytolysis, rhabdomyolysis and thrombotic/hemorrhagic events.
Conclusions: In this large cohort of hospitalized COVID-19 patients, statins were not independently associated with all-cause mortality during follow-up. Clinically relevant statin-associated adverse effects should be carefully monitored during hospital admission.
(© 2021 Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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