A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy.
| Autor: | Wirsing L; Department of Gastroenterology, Hepatology and Endocrinology, Robert-Bosch-Hospital, Stuttgart, Germany., Linzenbold W; ERBE Elektromedizin GmbH, Tuebingen, Germany., Jaeger SU; Department of Clinical Pharmacology, University Hospital, University of Tuebingen, Tuebingen, Germany.; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (IKP), Stuttgart, Germany., Stahl P; Department of Clinical Pathology, Robert-Bosch-Hospital, Stuttgart, Germany., Ott G; Department of Clinical Pathology, Robert-Bosch-Hospital, Stuttgart, Germany., Leibold T; Department of Surgery, Robert-Bosch-Hospital, Stuttgart, Germany., Enderle M; ERBE Elektromedizin GmbH, Tuebingen, Germany., Albert J; Department of Gastroenterology, Hepatology and Endocrinology, Robert-Bosch-Hospital, Stuttgart, Germany., Peveling-Oberhag J; Department of Gastroenterology, Hepatology and Endocrinology, Robert-Bosch-Hospital, Stuttgart, Germany. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Endoscopy international open [Endosc Int Open] 2022 Jun 10; Vol. 10 (6), pp. E809-E814. Date of Electronic Publication: 2022 Jun 10 (Print Publication: 2022). |
| DOI: | 10.1055/a-1797-8966 |
| Abstrakt: | Background and study aims Indeterminate biliary strictures represent a major challenge in clinical diagnostics. Diagnostic yield of radiological, endoscopic imaging and histopathological diagnosis is insufficient. The cryobiopsy technique is a new method for tissue extraction already used in different clinical settings. The aim of this ex vivo clinical study was to investigate feasibility and tissue quality of cryobiopsy in the bile duct. Patients and methods We included 14 patients who underwent pancreaticoduodenectomy. Bile duct samples were taken with either a new prototype cryoprobe or one of two forceps types. Results were analyzed for general feasibility, specimen size, histological assessability as well as representativity of retrieved tissue. Results Feasibility of cholangioscopic forceps was poor compared to gastric biopsy forceps or cryobiopsy. Significantly larger tissue samples were obtained with cryobiopsy (5.6 ± 4.5 mm 2 ) compared to gastric biopsy forceps (3.3 ± 5.1 mm 2 , P = 0.006). Furthermore, cryobiopsy was superior in histological assessment quality ( P = 0.02) and concerning representativity ( P = 0.03). Conclusions Cryobiopsy in the bile duct is feasible and the quality of the obtained tissue is high. Further investigation of bile duct cryobiopsy in vivo is warranted. Competing Interests: Competing interests The co-authors Walter Linzenbold and Markus Enderle are employees of ERBE Elektromedizin GmbH, Tuebingen, Germany. Cryoprobes were provided by ERBE Elektromedizin GmbH, Tuebingen, Germany. All other authors have no conflict of interest. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|