Effects of calcium silicate cements on neuronal conductivity.

Autor:	Deniz-Sungur D; Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey., Onur MA; Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey., Akbay E; Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey., Tan G; Department of Biology, Faculty of Science and Letters, Aksaray University, Aksaray, Turkey., Daglı-Comert F; Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.; Adult Restorative Dentistry and Endodontics, Oman Dental College, Muscat, Oman., Sayın TC; Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.; Private Practice, Fort Lauderdale, FL, USA.
Jazyk:	angličtina
Zdroj:	Restorative dentistry & endodontics [Restor Dent Endod] 2022 Mar 07; Vol. 47 (2), pp. e18. Date of Electronic Publication: 2022 Mar 07 (Print Publication: 2022).
DOI:	10.5395/rde.2022.47.e18
Abstrakt:	Objectives: This study evaluated alterations in neuronal conductivity related to calcium silicate cements (CSCs) by investigating compound action potentials (cAPs) in rat sciatic nerves. Materials and Methods: Sciatic nerves were placed in a Tyrode bath and cAPs were recorded before, during, and after the application of test materials for 60-minute control, application, and recovery measurements, respectively. Freshly prepared ProRoot MTA, MTA Angelus, Biodentine, Endosequence RRM-Putty, BioAggregate, and RetroMTA were directly applied onto the nerves. Biopac LabPro version 3.7 was used to record and analyze cAPs. The data were statistically analyzed. Results: None of the CSCs totally blocked cAPs. RetroMTA, Biodentine, and MTA Angelus caused no significant alteration in cAPs ( p > 0.05). Significantly lower cAPs were observed in recovery measurements for BioAggregate than in the control condition ( p < 0.05). ProRoot MTA significantly but transiently reduced cAPs in the application period compared to the control period ( p < 0.05). Endosequence RRM-Putty significantly reduced cAPs. Conclusions: Various CSCs may alter cAPs to some extent, but none of the CSCs irreversibly blocked them. The usage of fast-setting CSCs during apexification or regeneration of immature teeth seems safer than slow-setting CSCs due to their more favorable neuronal effects. Competing Interests: Conflict of Interest: No potential conflict of interest relevant to this article was reported. (Copyright © 2022. The Korean Academy of Conservative Dentistry.)
Databáze:	MEDLINE
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