Metabolic Syndrome in Behçets Disease Patients: Keep an Eye on the Eye.

Autor:	ElAdle SS; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Latif EA; Ophthalmology Department, Faculty of Medicine, Alexandria University, Egypt., Abdel-Fattah YH; Rheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Shebini EE; Internal Medicine Department, Rheumatology Unit, Menoufia University, Menoufia, Egypt., El-Gazzar II; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., El-Saadany HM; Rheumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt., Samy N; Internal Medicine Department, Faculty of Medicine, Rheumatology Unit, Ain-Shams University, Cairo, Egypt., El-Mallah R; Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Salem MN; Internal Medicine Department, Faculty of Medicine, Rheumatology Unit, Beni-Suef University, Beni-Suef, Egypt., Eesa N; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Shereef RE; Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt., El Khalifa M; Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Tharwat S; Internal Medicine Department, Faculty of Medicine, Mansoura University, Rheumatology Unit, Dakahlia, Egypt., Nasef SI; Rheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt., Ibrahim ME; Rheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt., Khalil NM; Internal Medicine Department, Faculty of Medicine, Cairo University, Rheumatology Unit, Cairo, Egypt., Abdalla AM; Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt., Abd Elazeem MI; Rheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt., Noor RA; Internal Medicine Department, Rheumatology Unit, Tanta University, Gharbia, Egypt., Sallam R; Rheumatology Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt., El-Bahnasawy A; Rheumatology Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt., Shanawany AE; Rheumatology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt., Senara S; Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Fathi HM; Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Bakry SAE; Internal Medicine Department, Faculty of Medicine, Rheumatology Unit, Ain-Shams University, Cairo, Egypt., Elsaman A; Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt., Najjar AE; Rheumatology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt., Ragab U; Internal Medicine Department, Clinical Immunology Unit, Zagazig University, Sharkia, Egypt., Talaat EA; Rheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt., Hammam N; Rheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt., El-Hindawy AK; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Gheita TA; Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Ismail F; Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt.
Jazyk:	angličtina
Zdroj:	Current rheumatology reviews [Curr Rheumatol Rev] 2023; Vol. 19 (2), pp. 180-188.
DOI:	10.2174/1573397118666220610123242
Abstrakt:	Background: Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pressure/ sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's Disease (BD) remains unclear. Aims: The aim was to determine the frequency of MetS among BD patients and to study its relationship with disease characteristics. Methods: The study included 1028 adult BD patients recruited from 18 specialized rheumatology centers. 51 healthy matched control were considered. Behçet Disease Current Activity Form (BDCAF) and the BD damage index (BDI) were estimated. Adult Treatment Panel-III criteria were used to define MetS. Results: The mean age of patients was 36.8 ± 10.1 years, M:F 2.7:1 and disease duration 7.01 ± 5.2 years. Their mean BDCAF was 5.1 ± 4.6 and BDI 5.5 ± 2.8. MetS was present in 22.8% of patients and in 5.9% of control (3.9 fold higher-risk). Patients with MetS had a significantly increased age at onset (31.8 ± 9.2 vs. 29 ± 8.5 years) and higher frequency of genital ulcers (96.2% vs. 79.7%), skin involvement (73.1% vs. 50.4%), arthritis (48.3% vs. 29.1%) (p<0.0001) and CNS manifestations (18.8% vs. 13%) (p=0.042) compared to those without it. Eye involvement was significantly increased in those with MetS (82.1% vs. 74.2%) (p=0.003) with increased frequency of posterior uveitis (67.1% vs. 43.5%), retinal vessel occlusion (35.9% vs. 21.3%), retinal vasculitis (41.9% vs. 26.4%) (p<0.0001) and vitritis (37.2% vs. 24%) (p=0.001). BDCAF was significantly lower (3.9 ± 4.3 vs. 5.6 ± 4.6) and BDI higher (7.4 ± 2.7vs5 ± 2.6) (p<0.0001). Conclusion: BD patients with MetS are predisposed to mucocutaneous, musculoskeletal, neuropsychiatric and ocular manifestations with consequently increased damage. The involvement of the deeper structures of the eye should alarm rheumatologists to keep in mind that all patients should have an eye examination, especially those with MetS. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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