Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results.

Autor:	Proffer SL; Mayo Clinic, Department of Dermatology, Rochester, MN, USA., Paradise CR; Rion Aesthetics, LLC, Rochester, MN, USA., DeGrazia E; Rion Aesthetics, LLC, Rochester, MN, USA., Halaas Y, Durairaj KK; Head & Neck/ENT Huntington Hospital, Pasadena, CA, USA., Somenek M, Sivly A; Mayo Clinic Knowledge and Evaluation Research Center, Rochester, MN, USA., Boon AJ; Mayo Clinic Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA., Behfar A; Mayo Clinic Department of Cardiovascular Diseases, Rochester, MN, USA., Wyles SP; Mayo Clinic, Department of Dermatology, Rochester, MN, USA.
Jazyk:	angličtina
Zdroj:	Aesthetic surgery journal [Aesthet Surg J] 2022 Sep 14; Vol. 42 (10), pp. 1185-1193.
DOI:	10.1093/asj/sjac149
Abstrakt:	Background: Exosomes are regenerative mediators for skin rejuvenation. Human platelet extract (HPE) is an allogeneic exosome product derived from US-sourced, leukocyte-reduced apheresed platelets with consistent purity and potency. Objectives: The authors sought to better characterize the safety and tolerability of novel HPE (plated) Intensive Repair Serum (Rion Aesthetics, Rochester, MN) and its maximal effects on skin rejuvenation at 6 weeks. Methods: This prospective, single-arm, non-randomized, longitudinal study investigated the safety and efficacy of HPE. Structured sub-analysis evaluated multifactorial improvement in skin health following standardized skin care regimen to determine the maximal effect. Evaluation at baseline and 6 weeks included participant questionnaires and photo documentation with VISIA-CR Generation 5 3D PRIMOS (Canfield Scientific Inc, Fairfield, NJ). Results: VISIA-CR imaging yielded quantifiable and statistically significant improvements in overall skin health (skin health score). A greater score correlated to greater overall skin health, and there was a statistically significant mean delta improvement of 224.2 ± 112.8 (mean ± standard deviation, P ≤ 0.0001) in skin health score at 6 weeks compared with baseline. This correlated to reduction in redness, wrinkles, and melanin production across all cosmetic units (P = 0.005, P = 0.0023, P ≤ 0.0001, respectively) and significant improvements in luminosity and color evenness (P ≤ 0.001). Conclusions: A topically applied platelet-derived exosome product, HPE, induced normalization to skin health at 4 to 6 weeks with improved various clinical measures of facial photodamage and cutaneous aging. It is safe, well-tolerated, and well-liked by participants. (© The Author(s) 2022. Published by Oxford University Press on behalf of The Aesthetic Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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