COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.

Autor: Schrijver IT; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Théroude C; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Antonakos N; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Regina J; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Le Roy D; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Bart PA; Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Chiche JD; Service of Adult Intensive Care Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Perreau M; Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Pantaleo G; Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Calandra T; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Roger T; Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2022 Oct; Vol. 52 (10), pp. 1676-1679. Date of Electronic Publication: 2022 Jun 24.
DOI: 10.1002/eji.202249827
Abstrakt: We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
(© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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