Employment trajectories of young women with breast cancer: an ongoing prospective cohort study in Italy and Switzerland.

Autor: Ribi K; Quality of Life Office, International Breast Cancer Study Group, Bern, Switzerland. karin.ribi@etop.ibcsg.org., Pagan E; Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy., Sala I; Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy., Ruggeri M; Program for Young Patients, International Breast Cancer Study Group, Bern, Switzerland., Bianco N; Division of Medical Senology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Bucci EO; Breast Cancer Unit, OspedaleMultiMedica, Castellanza, VA, Italy., Graffeo R; Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland., Borner M; Division of Oncology (Oncocare), Klinik Engeried, Lindenhofgruppe, Bern, Switzerland., Giordano M; ASST-Lariana, Como, Italy., Gianni L; Department of Medical Oncology, Ospedale Infermi, AUSL Della Romagna, Rimini, Italy., Rabaglio M; Department of Medical Oncology, Bern University Hospital, University of Bern, Inselspital, Bern, Switzerland., Freschi A; Department of Medical Oncology, CRO, Aviano, Italy., Cretella E; Department of Medical Oncology, Azienda Sanitaria Dell'Alto Adige, Bolzano, Italy., Seles E; Department of Medical Oncology, Ospedale degli Infermi, Biella, Italy., Farolfi A; Department of Medical Oncology, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Simoncini E; Breast Unit, ASST Spedali Civili Di Brescia, Brescia, Italy., Ciccarese M; U.O. Oncologia Medica, Vito Fazzi Hospital, Lecce, Italy., Rauch D; Medical Oncology, Spital STS, Thun, Switzerland., Favaretto A; Medical Oncology Unit, Azienda ULSS2 Marca Trevigiana, Treviso, Italy., Glaus A; Tumor- and Breast Center ZeTuP, St. Gallen, Switzerland., Berardi R; Department of Medical Oncology, Università Politecnica Delle Marche, A.O.U. Ospedali Riuniti Di Ancona, Ancona, Italy., Franzetti-Pellanda A; Radiotherapy Service, Clinica Luganese Moncucco, Lugano, Switzerland., Bagnardi V; Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy., Gelber S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Partridge AH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Goldhirsch A; International Breast Cancer Study Group, IEO European Institute of Oncology, IRCCS, Milan, Italy., Pagani O; Swiss Group for Clinical Cancer Research (SAKK), Interdisciplinary Cancer Service Hospital Riviera-Chablais Rennaz, Vaud, Geneva University Hospitals, Lugano University, Lugano, Switzerland.
Jazyk: angličtina
Zdroj: Journal of cancer survivorship : research and practice [J Cancer Surviv] 2023 Dec; Vol. 17 (6), pp. 1847-1858. Date of Electronic Publication: 2022 Jun 10.
DOI: 10.1007/s11764-022-01222-y
Abstrakt: Purpose: Despite extensive research on cancer and work-related outcomes, evidence from longitudinal cohort studies is limited, especially in young women with breast cancer (BC). We aimed to investigate employment trajectories in young BC survivors and to identify potential factors associated with changes in work activity.
Methods: The HOHO European prospective multicenter cohort study enrolled 300 young women (≤ 40 years) with newly diagnosed BC. Women completed surveys at baseline and every 6 months for 3 years, then yearly for up to 10 years to assess, among other variables, employment status, sociodemographic, medical, and treatment data. Symptoms were assessed by the Breast Cancer Prevention Trial symptom scales and single items from the Cancer Rehabilitation Evaluation System. Univariable and multivariable multinomial logistic regression analyses identified factors associated with changes in employment status.
Results: Among the 245 women included in this analysis, 85% were employed at the last individual post-baseline assessment (1 to 10 years). At 5 years, women had a 29.4% probability (95% CI: 23.6-35.5) of experiencing any reduction and a 14.9% probability (95% CI: 10.6-19.9) of experiencing any increase in work activities. Being enrolled in Switzerland (vs. Italy) and reporting more trouble in performing daily activities were significantly associated with work reduction.
Conclusion: Our results suggest that most young BC survivors remain employed in the long-term.
Implications for Cancer Survivors: Regular evaluation of symptoms which may interfere with daily life and identification of financial discomfort is critical in providing timely and individually tailored interventions and in limiting unwanted reductions in work activities.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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