Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the "NELA" birth cohort.

Autor: Navarro-Lafuente F; University of Murcia, Murcia, Spain., Adoamnei E; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain. Electronic address: evdochia.adoamnei@um.es., Arense-Gonzalo JJ; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain., Prieto-Sánchez MT; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain., Sánchez-Ferrer ML; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain., Parrado A; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain., Fernández MF; University of Granada, Centro de Investigación Biomédica, Granada, Spain; Instituto de Investigación Biosanitaria Ibs. Granada, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Instituto de Salud Carlos III, Madrid, Spain., Suarez B; University of Granada, Centro de Investigación Biomédica, Granada, Spain; Instituto de Investigación Biosanitaria Ibs. Granada, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Instituto de Salud Carlos III, Madrid, Spain., López-Acosta A; 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain., Sánchez-Guillamón A; 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain., García-Marcos L; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain; Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Spain., Morales E; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain., Mendiola J; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Instituto de Salud Carlos III, Madrid, Spain., Torres-Cantero AM; University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB), Murcia, Spain; 'Virgen de la Arrixaca' University Clinical Hospital, Murcia, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2022 Sep 10; Vol. 838 (Pt 4), pp. 156540. Date of Electronic Publication: 2022 Jun 07.
DOI: 10.1016/j.scitotenv.2022.156540
Abstrakt: Endocrine disrupting chemicals (EDCs) set a public health risk through disruption of normal physiological processes. The toxicoepigenetic mechanisms of developmental exposure to common EDCs, such as bisphenol A (BPA), are poorly known. The present study aimed to evaluate associations between perinatal maternal urinary concentrations of BPA, bisphenol S (BPS) and bisphenol F (BPF) and LINE-1 (long interspersed nuclear elements) and Alu (short interspersed nuclear elements, SINEs) DNA methylation levels in newborns, as surrogate markers of global DNA methylation. Data come from 318 mother-child pairs of the `Nutrition in Early Life and Asthma´ (NELA) birth cohort. Urinary bisphenol concentration was measured by dispersive liquid-liquid microextraction and ultrahigh performance liquid chromatography with tandem mass spectrometry detection. DNA methylation was quantitatively assessed by bisulphite pyrosequencing on 3 LINEs and 5 SINEs. Unadjusted linear regression analyses showed that higher concentration of maternal urinary BPA in 24th week's pregnancy was associated with an increase in LINE-1 methylation in all newborns (p = 0.01) and, particularly, in male newborns (p = 0.03). These associations remained in full adjusted models [beta = 0.09 (95 % CI = 0.03; 0.14) for all newborns; and beta = 0.10 (95 % CI = 0.03; 0.17) for males], including a non-linear association for female newborns as well (p-trend = 0.003). No associations were found between maternal concentrations of bisphenol and Alu sequences. Our results suggest that exposure to environmental levels of BPA may be associated with a modest increase in LINE-1 methylation -as a relevant marker of epigenomic stability- during human fetal development. However, any effects on global DNA methylation are likely to be small, and of uncertain biological significance.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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