Non-HDL Cholesterol, Obesity, and Metabolic Syndrome in Epileptic Patients.

Autor:	Khuda IE; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Nazish S; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.; Corresponding author: Saima Nazish, MBBS, FEBN, FCPS, Department of Neurology, King Fahd Hospital of University, Imam Abdulrahman Bin Faisal University, Khobar, Eastern Province, Saudi Arabia 31952 (snmohammadali@iau.edu.sa)., Zeeshan MA; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Shariff E; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Aljaafari D; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Alabdali M; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	The primary care companion for CNS disorders [Prim Care Companion CNS Disord] 2022 Jun 07; Vol. 24 (3). Date of Electronic Publication: 2022 Jun 07.
DOI:	10.4088/PCC.21m03057
Abstrakt:	Objective: To compare cardiovascular risk factors in patients with epilepsy with those of non-epileptic neurologic patients to determine their association with antiepileptic drug therapy. Methods: This observational study with a cross-sectional design was performed in a tertiary care hospital in the Eastern Province of Saudi Arabia from January to December 2018. A total of 110 patients with epilepsy were included in the study, along with 46 age- and sex-matched non-epileptic controls (approximate ratio of 2:1). Blood pressure reading (BP), anthropometric measurements, fasting blood sugar levels, and fasting lipid profiles were performed for all subjects. Results: Raised non-high-density lipid cholesterol (nHDLC) was the most common cardiovascular risk in epileptic patients, with a frequency of 51% compared to 30.4% in controls ( P  = .019). Epileptic patients who were male (58.3%, 28/48, P  = .012) and those aged < 35 years (47.3%, 26/55, P  = .036) were more likely to have high nHDLC. Obesity was also common in epileptic patients with frequency of 49.1% (n = 54) versus 30.4% (n = 14) in controls ( P  = .032). Metabolic syndrome was present in 26.3% of epileptic patients versus 23.9% of controls ( P  = .749). Among the epileptic patients, of those with high nHDLC, 85.7% had satisfactory seizure control ( P  = .019). Conclusions: Raised nHDLC and obesity but not metabolic syndrome appear to be highly prevalent in epileptic patients compared to those without epilepsy. Antiepileptic drugs alone may not play a role in developing high lipid levels. More studies are needed to determine the causes of higher risk factor profile in epileptic patients and their relationship with seizure control. (© Copyright 2022 Physicians Postgraduate Press, Inc.)
Databáze:	MEDLINE
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