| Autor: |
Asiwe JN; Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Nigeria.; Department of Physiology, University of Ibadan, Ibadan, Nigeria., Kolawole TA; Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Nigeria., Buduburisi BR; Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Nigeria., Adebayo OG; Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Nigeria., Onuoha OG; Department of Physiology, PAMO University of Medical Sciences, Port Harcourt, Nigeria., Inegbenehi S; Department of Biochemistry, PAMO University of Medical Sciences, Port Harcourt, Nigeria., Ademilusi EO; Department of Physiology, University of Ibadan, Ibadan, Nigeria., Dapper DV; Department of Physiology, University of Port-Harcourt, Port Harcourt, Nigeria. |
| Abstrakt: |
Lead is a hazardous naturally found heavy metal that has been reported to induce haematological alterations. Whether cabbage, a commonly consumed vegetable rich in antioxidants and anticancer compounds, can mitigate these alterations remains unknown. This study investigated the protective effect of cabbage juice against Lead-induced haematological changes. Twenty (20) male Wistar rats were randomly selected into four groups (n = 5) and given distilled water (1 ml/100 g b.wt ), Lead acetate (25 mg/kg b.wt ), Cabbage juice (1 ml/100 g b.wt ), and Lead acetate with Cabbage juice. All treatments were given orally for 28 days. Lead exposure induces normocytic normochromic anemia with substantial leukocytosis, lymphocytopenia, and hyperfibrinogenemia. Lead-intoxicated animals had significantly higher haemolysis and prolonged clotting times. However, cabbage juice reverses these adverse haematological and haemorheological changes induced by Lead acetate. Conclusively, cabbage juice demonstrated antioxidant, anti-inflammatory, anti-thrombotic, and immunomodulatory properties, as well as the ability to protect the red blood cell membrane from damage caused by Lead-induced osmotic stress. |
