The BILAG-2004 index is associated with development of new damage in SLE.

Autor:	Yee CS; Department of Rheumatology, Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Doncaster., Gordon C; Rheumatology Research Group, Institute of Inflammation of Ageing, University of Birmingham, Birmingham., Akil M; Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield., Lanyon P; Department of Rheumatology, Nottingham University Hospitals NHS Trust, Nottingham., Edwards CJ; Musculoskeletal Research Unit, NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton., Isenberg DA; Centre For Rheumatology, Division of Medicine, University College London, London., Rahman A; Centre For Rheumatology, Division of Medicine, University College London, London., Teh LS; Department of Rheumatology, Royal Blackburn Teaching Hospital, Blackburn.; Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston., Tosounidou S; Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham., Stevens R; Department of Rheumatology, Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Doncaster., Prabu A; Rheumatology Research Group, Institute of Inflammation of Ageing, University of Birmingham, Birmingham., Griffiths B; Department of Rheumatology, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne., McHugh N; Department of Pharmacy and Pharmacology, University of Bath, Bath., Bruce IN; Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester., Ahmad Y; Department of Rheumatology, Betsi Cadwaladr University Health Board, Wales., Khamashta MA; Women & Children's Health, King's College London, London., Farewell VT; MRC Biostatistics Unit, Universtiy of Cambridge, Cambridge, UK.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Feb 01; Vol. 62 (2), pp. 668-675.
DOI:	10.1093/rheumatology/keac334
Abstrakt:	Objective: To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined. Methods: This was a multicentre longitudinal study. Patients were recruited within 12 months of achieving fourth ACR classification criterion for SLE. Data were collected on disease activity, damage, SLE-specific drug exposure, cardiovascular risk factors, antiphospholipid syndrome status and death at every visit. This study ran from 1 January 2005 to 31 December 2017. Descriptive statistics were used to analyse mortality and development of new damage. Poisson regression was used to examine potential explanatory variables for development of new damage. Results: A total of 273 SLE patients were recruited with total follow-up of 1767 patient-years (median 73.4 months). There were 6348 assessments with disease activity scores available for analysis. During follow-up, 13 deaths and 114 new damage items (in 83 patients) occurred. The incidence rate for development of damage was higher in the first 3 years before stabilizing at a lower rate. Overall rate for damage accrual was 61.1 per 1000 person-years (95% CI: 50.6, 73.8). Analysis showed that active disease scores according to BILAG-2004 index (systems scores of A or B, counts of systems with A and BILAG-2004 numerical score) were associated with development of new damage. Low disease activity (LDA) states [BILAG-2004 LDA and BILAG Systems Tally (BST) persistent LDA] were inversely associated with development of damage. Conclusions: BILAG-2004 index is associated with new damage. BILAG-2004 LDA and BST persistent LDA can be considered as treatment targets. (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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