Evolutionary Dynamics of Begomoviruses and Its Satellites Infecting Papaya in India.

Autor:	Srivastava A; Department of Biotechnology, D.D.U. Gorakhpur University, Gorakhpur, India., Pandey V; Department of Biotechnology, D.D.U. Gorakhpur University, Gorakhpur, India., Sahu AK; International Center for Genetic Engineering and Biotechnology, New Delhi, India., Yadav D; Department of Biotechnology, D.D.U. Gorakhpur University, Gorakhpur, India., Al-Sadi AM; Department of Plant Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al-Khod, Oman., Shahid MS; Department of Plant Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al-Khod, Oman., Gaur RK; Department of Biotechnology, D.D.U. Gorakhpur University, Gorakhpur, India.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2022 May 12; Vol. 13, pp. 879413. Date of Electronic Publication: 2022 May 12 (Print Publication: 2022).
DOI:	10.3389/fmicb.2022.879413
Abstrakt:	The genus Begomovirus represents a group of multipartite viruses that significantly damage many agricultural crops, including papaya, and influence overall production. Papaya leaf curl disease (PaLCD) caused by the complex begomovirus species has several important implications and substantial losses in papaya production in many developing countries, including India. The increase in the number of begomovirus species poses a continuous threat to the overall production of papaya. Here, we attempted to map the genomic variation, mutation, evolution rate, and recombination to know the disease complexity and successful adaptation of PaLCD in India. For this, we retrieved 44 DNA-A and 26 betasatellite sequences from GenBank reported from India. An uneven distribution of evolutionary divergence has been observed using the maximum-likelihood algorithm across the branch length. Although there were phylogenetic differences, we found high rates of nucleotide substitution mutation in both viral and sub-viral genome datasets. We demonstrated frequent recombination of begomovirus species, with a maximum in intra-species recombinants. Furthermore, our results showed a high degree of genetic variability, demographic selection, and mean substitution rate acting on the population, supporting the emergence of a diverse and purifying selection of viruses and associated betasatellites. Moreover, variation in the genetic composition of all begomovirus datasets revealed a predominance of nucleotide diversity principally driven by mutation, which might further accelerate the advent of new strains and species and their adaption to various hosts with unique pathogenicity. Therefore, the finding of genetic variation and selection emphases on factors that contribute to the universal spread and evolution of Begomovirus and this unanticipated diversity may also provide guidelines toward future evolutionary trend analyses and the development of wide-ranging disease control strategies for begomoviruses associated with PaLCD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Srivastava, Pandey, Sahu, Yadav, Al-Sadi, Shahid and Gaur.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu