A Case of Type 1 Triallelic Patterns at D5S818, D18S51, D6S1043, and FGA Demonstrated by Short Tandem Repeat Analysis.

Autor: Fan J; Department of Hematology Oncology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China., Zhang AP; Medical School of Jianghan University, Wuhan Economic and Technological Development Zone, Wuhan 430056, China., Zheng ZZ; Shanghai Tissuebank Biotechnology Co., Ltd, Shanghai 201201, China., An L; Shanghai Tissuebank Biotechnology Co., Ltd, Shanghai 201201, China., Xiao PL; Shanghai Tissuebank Biotechnology Co., Ltd, Shanghai 201201, China., Li DY; Shanghai Tissuebank Biotechnology Co., Ltd, Shanghai 201201, China., Du KM; Shanghai Tissuebank Biotechnology Co., Ltd, Shanghai 201201, China., Xiong H; Department of Hematology Oncology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China.
Jazyk: angličtina
Zdroj: International journal of clinical practice [Int J Clin Pract] 2022 Apr 25; Vol. 2022, pp. 8600125. Date of Electronic Publication: 2022 Apr 25 (Print Publication: 2022).
DOI: 10.1155/2022/8600125
Abstrakt: The triallelic pattern of short tandem repeat (STR) is rare; especially, the case where this pattern exists at 4 loci has not been reported. Here, we report the type 1 triallelic patterns at D5S818, D18S51, D6S1043, and FGA from a Chinese family, which were observed during our routine chimerism assays. Before hematopoietic stem cell transplantation, the blood sample of the certain patient was analyzed by performing chimerism analysis. A preliminary STR analysis was also performed on the samples of the patient's parents. STR signal data illustrated that the sum of the peak chart areas of the two types inherited from the father was basically the same as that of the mother, belonging to the type 1 triallelic pattern. In addition, the patient's elder sister's STR result appeared to be normal. Altogether, we presented a pedigree, in which the triallelic pattern was linked by inheritance in the family. This is the first reported case of the triallelic pattern at D5S818, D18S51, D6S1043, and FGA all around the world. We hope that in the future there will be any tools to achieve accurate verification against this possibility.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Jing Fan et al.)
Databáze: MEDLINE
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