Highly enantioselective copper-catalyzed propargylic amination to access N -tethered 1,6-enynes.

Autor:	Li SJ; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn., Huang J; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn., He JY; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn., Zhang RJ; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn., Qian HD; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn., Dai XL; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn., Kong HH; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn., Xu H; CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University 152 Luoyu Road Wuhan Hubei 430079 China hao.xu@ccnu.edu.cn.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2020 Oct 20; Vol. 10 (63), pp. 38478-38483. Date of Electronic Publication: 2020 Oct 20 (Print Publication: 2020).
DOI:	10.1039/d0ra07698h
Abstrakt:	A highly enantioselective copper-catalyzed propargylic amination starting from benzylic allylic amines has been developed with a new chiral N,N,P ligand. A series of N -tethered 1,6-enynes were synthesized in good to excellent yields with excellent enantioselectivities. Utilization of transition metal-catalyzed cycloisomerization of 1,6-enynes provides several enantioselectively enriched chiral five-membered N-heterocycles efficiently. Competing Interests: The authors declare no competing financial interest. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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