A South African Breast Implant-Associated Anaplastic Large Cell Lymphoma: Clinical Presentation and Six-Year Follow-Up.

Autor: Grubnik A; Netcare Breast Care Centre of Excellence, Milpark Hospital, 9 Guild Road Parktown, South Africa., Ramdas Y; Netcare Breast Care Centre of Excellence, Milpark Hospital, 9 Guild Road Parktown, South Africa.; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Corner Doctor Savage Road and Bophelo Road, Pretoria 0002, South Africa., Van der Bergh B; Netcare Breast Care Centre of Excellence, Milpark Hospital, 9 Guild Road Parktown, South Africa., Nayler S; Netcare Breast Care Centre of Excellence, Milpark Hospital, 9 Guild Road Parktown, South Africa.; Drs Gritzman & Thatcher Inc. Laboratories, 4 Main Street, Bordeaux, Randburg, Johannesburg 2194, South Africa.; University of the Witwatersrand, Donald Gordon Medical Centre, 21 Eton Road, Parktown Johannesburg, 2193, South Africa., Benn CA; Netcare Breast Care Centre of Excellence, Milpark Hospital, 9 Guild Road Parktown, South Africa.; Helen Joseph Hospital Breast Care Clinic, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, 1 Perth Road, Auckland Park, Johannesburg, 2092 Gauteng, South Africa., Rapoport BL; Netcare Breast Care Centre of Excellence, Milpark Hospital, 9 Guild Road Parktown, South Africa.; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Corner Doctor Savage Road and Bophelo Road, Pretoria 0002, South Africa.; The Medical Oncology Centre of Rosebank, 129 Oxford Road, Johannesburg 2196, South Africa.
Jazyk: angličtina
Zdroj: Case reports in oncological medicine [Case Rep Oncol Med] 2022 May 31; Vol. 2022, pp. 4162832. Date of Electronic Publication: 2022 May 31 (Print Publication: 2022).
DOI: 10.1155/2022/4162832
Abstrakt: Breast augmentation is the most common surgical procedure for women globally, with 1,795,551 cases performed in 2019. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is highly uncommon, with 733 reported cases as of January 2020. In South Africa, there are less than 4000 breast augmentation surgeries annually. This case presents the first case report documentation of a South African woman diagnosed with BIA-ALCL. The patient was a 61-year-old woman who consulted the Breast Care Centre of Excellence in Johannesburg in 2015. She had a prior history of bilateral augmentation mammoplasty with subsequent implant exchange. The patient presented with periprosthetic fluid with a mass-like enhancement on the left breast. Aspiration of the mass-like fluid was positive for CD45, CD30, and CD68 and negative for CD20 and ALK-1, indicative of BIA-ALCL. Surgical treatment included bilateral explantation, complete capsulectomies, and bilateral mastopexy. Macroscopic examination of the left breast capsulectomy demonstrated fibrous connective tissue. The histological examination of the tumor showed extensive areas of broad coagulative necrosis with foamy histiocytes. Immunohistochemistry examination of this tumor showed CD3-, CD20-, and ALK-1-negative and CD30- and CD68-positive stains. PCR analysis for T-cell clonality showed monoclonal T-cell expansion. These findings confirm the presence of BIA-ALCL. The patient recovered well after surgery and did not require adjuvant therapy. A patient with a confirmed diagnosis of BIA-ALCL was successfully treated with explantation and complete capsulectomy. She was followed up regularly for six years, and the patient remains well and in remission.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Alexandra Grubnik et al.)
Databáze: MEDLINE
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