Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults.

Autor:	Marcos-Vidal L; Universidad Carlos III de Madrid, Madrid, Spain.; Instituto de Investigación Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica En Red de Salud Mental, Madrid, Spain., Martínez-García M; Instituto de Investigación Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica En Red de Salud Mental, Madrid, Spain., Martín de Blas D; Instituto de Investigación Gregorio Marañón, Madrid, Spain., Navas-Sánchez FJ; Instituto de Investigación Gregorio Marañón, Madrid, Spain., Pretus C; Unitat de Reserca en Neurociencia Cognitiva, Departament de Psiquiatría i Neurociencia Legal, Universitat Autònoma de Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain., Ramos-Quiroga JA; Centro de Investigación Biomédica En Red de Salud Mental, Madrid, Spain.; Psychiatry Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute, Barcelona, Spain., Richarte V; Centro de Investigación Biomédica En Red de Salud Mental, Madrid, Spain.; Psychiatry Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute, Barcelona, Spain., Vilarroya Ó; Unitat de Reserca en Neurociencia Cognitiva, Departament de Psiquiatría i Neurociencia Legal, Universitat Autònoma de Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain., Sepulcre J; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Desco M; Universidad Carlos III de Madrid, Madrid, Spain.; Instituto de Investigación Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica En Red de Salud Mental, Madrid, Spain.; Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Carmona S; Universidad Carlos III de Madrid, Madrid, Spain.; Instituto de Investigación Gregorio Marañón, Madrid, Spain.; Centro de Investigación Biomédica En Red de Salud Mental, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Journal of attention disorders [J Atten Disord] 2022 Nov; Vol. 26 (13), pp. 1788-1801. Date of Electronic Publication: 2022 Jun 09.
DOI:	10.1177/10870547221101646
Abstrakt:	Objective: Neuroimaging studies in children with ADHD indicate that their brain exhibits an atypical functional connectivity pattern characterized by increased local connectivity and decreased distant connectivity. We aim to evaluate if the local and distant distribution of functional connectivity is also altered in adult samples with ADHD who have never received medication before. Methods: We compared local and distant functional connectivity between 31 medication-naïve adults with ADHD and 31 healthy controls and tested whether this pattern was associated with symptoms severity scores. Results: ADHD sample showed increased local connectivity in the dACC and the SFG and decreased local connectivity in the PCC. Conclusion : Results parallel those obtained in children samples suggesting a deficient integration within the DMN and segregation between DMN, FPN, and VAN. These results are consistent with the three main frameworks that explain ADHD: the neurodevelopmental delay hypothesis, the DMN interference hypothesis, and multi-network models.
Databáze:	MEDLINE
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