| Autor: |
Mukusheva GK; Karaganda Buketov University, Karaganda 100024, Kazakhstan., Zhasymbekova AR; Karaganda Buketov University, Karaganda 100024, Kazakhstan., Seidakhmetova RB; Karaganda Buketov University, Karaganda 100024, Kazakhstan., Nurkenov OA; Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan., Akishina EA; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus., Petkevich SK; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus., Dikusar EA; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus., Potkin VI; Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus. |
| Abstrakt: |
An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds 2e , 3b , 3c and 3e with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid. |
