| Autor: |
Oziębło D; Department of Genetics, Institute of Physiology and Pathology of Hearing, 02-042 Warsaw, Poland., Bałdyga N; Department of Genetics, Institute of Physiology and Pathology of Hearing, 02-042 Warsaw, Poland., Leja ML; Department of Genetics, Institute of Physiology and Pathology of Hearing, 02-042 Warsaw, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland., Skarżyński H; Oto-Rhino-Laryngology Surgery Clinic, Institute of Physiology and Pathology of Hearing, 02-042 Warsaw, Poland., Ołdak M; Department of Genetics, Institute of Physiology and Pathology of Hearing, 02-042 Warsaw, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2022 May 27; Vol. 23 (11). Date of Electronic Publication: 2022 May 27. |
| DOI: |
10.3390/ijms23116029 |
| Abstrakt: |
Hearing is an important human sense for communicating and connecting with others. Partial deafness (PD) is a common hearing problem, in which there is a down-sloping audiogram. In this study, we apply a practical system for classifying PD patients, used for treatment purposes, to distinguish two groups of patients: one with almost normal hearing thresholds at low frequencies (PDT-EC, n = 20), and a second group with poorer thresholds at those same low frequencies (PDT-EAS, n = 20). After performing comprehensive genetic testing with a panel of 237 genes, we found that genetic factors can explain a significant proportion of both PDT-EC and PDT-EAS hearing losses, accounting, respectively, for approx. one-fifth and one-half of all the cases in our cohort. Most of the causative variants were located in dominant and recessive genes previously linked to PD, but more than half of the variants were novel. Among the contributors to PDT-EC we identified OSBPL2 and SYNE4 , two relatively new hereditary hearing loss genes with a low publication profile. Our study revealed that, for all PD patients, a postlingual hearing loss more severe in the low-frequency range is associated with a higher detection rate of causative variants. Isolating a genetic cause of PD is important in terms of prognosis, therapeutic effectiveness, and risk of recurrence. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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