| Autor: |
Koyilot MC; Molecular Robotics, Cochin 682033, India., Natarajan P; Molecular Robotics, Cochin 682033, India., Hunt CR; Houston Methodist Research Institute, Houston, TX 77030, USA., Sivarajkumar S; Molecular Robotics, Cochin 682033, India., Roy R; Molecular Robotics, Cochin 682033, India., Joglekar S; Molecular Robotics, Cochin 682033, India., Pandita S; Mays Cancer Center, University of Texas Health Sciences Center at San Antonio, San Antonio, TX 78229, USA., Tong CW; School of Engineering Medicine, Texas A&M University, Houston, TX 77030, USA., Marakkar S; Molecular Robotics, Cochin 682033, India., Subramanian L; Courant Institute of Mathematical Science, New York University, New York, NY 10012, USA., Yadav SS; Department of Immunology, UT MD Anderson Cancer Center, Houston, TX 77030, USA., Cherian AV; Molecular Robotics, Cochin 682033, India., Pandita TK; Houston Methodist Research Institute, Houston, TX 77030, USA.; Center for Genomic and Precision Medicine, Institute of Biosciences and Technology, Department of Translational Medical Sciences, Texas A&M University, Houston, TX 77030, USA., Shameer K; School of Public Health, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK., Yadav KK; School of Engineering Medicine, Texas A&M University, Houston, TX 77030, USA.; Center for Genomic and Precision Medicine, Institute of Biosciences and Technology, Department of Translational Medical Sciences, Texas A&M University, Houston, TX 77030, USA. |
| Abstrakt: |
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous advantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease modelling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems. |
