Fish Hydrolysate Supplementation Prevents Stress-Induced Dysregulation of Hippocampal Proteins Relative to Mitochondrial Metabolism and the Neuronal Network in Mice.

Autor:	Le Faouder J; Abyss Ingredients, 56850 Caudan, France.; Protim Core Facility, Biosit UAR 3480 US_S 018, CNRS, Inserm, Rennes University, 35000 Rennes, France., Arnaud B; Protim Core Facility, Biosit UAR 3480 US_S 018, CNRS, Inserm, Rennes University, 35000 Rennes, France., Lavigne R; Protim Core Facility, Biosit UAR 3480 US_S 018, CNRS, Inserm, Rennes University, 35000 Rennes, France.; Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, EHESP, Inserm, Rennes University, 35042 Rennes, France., Lucas C; NutriBrain Research and Technology Transfer, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France.; NutriNeuro, INRAE, Bordeaux INP, Bordeaux University, 33076 Bordeaux, France., Com E; Protim Core Facility, Biosit UAR 3480 US_S 018, CNRS, Inserm, Rennes University, 35000 Rennes, France.; Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, EHESP, Inserm, Rennes University, 35042 Rennes, France., Bouvret E; Abyss Ingredients, 56850 Caudan, France., Dinel AL; NutriBrain Research and Technology Transfer, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France.; NutriNeuro, INRAE, Bordeaux INP, Bordeaux University, 33076 Bordeaux, France., Pineau C; Protim Core Facility, Biosit UAR 3480 US_S 018, CNRS, Inserm, Rennes University, 35000 Rennes, France.; Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, EHESP, Inserm, Rennes University, 35042 Rennes, France.
Jazyk:	angličtina
Zdroj:	Foods (Basel, Switzerland) [Foods] 2022 May 28; Vol. 11 (11). Date of Electronic Publication: 2022 May 28.
DOI:	10.3390/foods11111591
Abstrakt:	Over the past several decades, stress has dramatically increased in occidental societies. The use of natural resources, such as fish hydrolysates, may be an attractive strategy to improve stress management. Our previous study demonstrated the anxiolytic effects of fish hydrolysate supplementation in mice exposed to acute mild stress by limiting stress-induced corticosterone release and modulating the expression of a number of stress-responsive genes. Here, we explore hippocampal protein modulation induced by fish hydrolysate supplementation in mice submitted to acute mild stress, with the aim of better elucidating the underlying mechanisms. Hippocampi from the same cohort of Balb/c mice supplemented with fish hydrolysate (300 mg·kg -1 body weight) or vehicle daily for seven days before being submitted or not to an acute mild stress protocol (four groups, n = 8/group) were subjected to label-free quantitative proteomics analysis combined with gene ontology data mining. Our results show that fish hydrolysate supplementation prevented the observed stress-induced dysregulation of proteins relative to mitochondrial pathways and the neuronal network. These findings suggest that fish hydrolysate represents an innovative strategy to prevent the adverse effects of stress and participate in stress management.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu