Olfaction and apathy in early idiopathic Parkinson's disease.

Autor: Martinez-Nunez AE; Department of Neurology, Henry Ford Health System, Detroit, MI, USA., Latack K; Biostatistics, Henry Ford Health System, Detroit, MI, USA., Situ-Kcomt M; Department of Neurology, University of Nebraska Medical Center, Omaha, NE, USA., Mahajan A; Department of Neurological Sciences, Rush Parkinson's disease and Movement disorders program, Chicago, IL, USA. Electronic address: Abhimanyu_Mahajan@rush.edu.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2022 Aug 15; Vol. 439, pp. 120314. Date of Electronic Publication: 2022 Jun 03.
DOI: 10.1016/j.jns.2022.120314
Abstrakt: Background: Apathy remains a disabling symptom in Parkinson's disease (PD) with limited therapeutic success. Processing of emotions and smell share neuroanatomical and evolutionary pathways.
Objectives: To explore the association of apathy with smell dysfunction (SD) in early PD.
Methods: We analyzed patients with de-novo PD, with follow-up of at least 5 years from the Parkinson's Progression Markers Initiative. SD and apathy were defined using University of Pennsylvania Smell Identification Test and MDS-UPDRS part 1A. Odds ratios were calculated between apathy and olfaction groups. Kaplan-Meier survival analysis was grouped by presence/ absence of smell dysfunction. The Log Rank test was used to compare time to apathy.
Results: We found no association between presence of apathy in patients with and without SD (OR 1.01 [0.49-2.08]). There was no significant difference between PD patients with and without SD in time to apathy (p = 0.72).
Conclusions: SD does not portend greater risk of apathy in PD.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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