Sugars measured enzymatically in a fasting overnight urine sample are not sensitive biomarkers of dietary added sugar intake in postmenopausal women.

Autor:	Weinhold KR; Human Sciences Department, College of Education and Human Ecology, 2647The Ohio State University, Columbus, OH, USA., Andridge RR; Division of Biostatistics, College of Public Health, 2647The Ohio State University, Columbus, OH, USA., Bomser JA; Human Sciences Department, College of Education and Human Ecology, 2647The Ohio State University, Columbus, OH, USA., Sasaki GY; Human Sciences Department, College of Education and Human Ecology, 2647The Ohio State University, Columbus, OH, USA., Bruno RS; Human Sciences Department, College of Education and Human Ecology, 2647The Ohio State University, Columbus, OH, USA., Orchard TS; Human Sciences Department, College of Education and Human Ecology, 2647The Ohio State University, Columbus, OH, USA.
Jazyk:	angličtina
Zdroj:	Nutrition and health [Nutr Health] 2022 Jun 09, pp. 2601060221106819. Date of Electronic Publication: 2022 Jun 09.
DOI:	10.1177/02601060221106819
Abstrakt:	Background: Restricting dietary sugar is a leading recommendation, but limited biomarkers assessing intake exist. Although 24-h urinary sucrose (U-Suc) and urinary fructose (U-Fruc) excretion has been used with mixed success, collection is burdensome. Aim: This study aimed to test the sensitivity of an enzymatic assay of U-Suc and U-Fruc to detect changing added sugar intake using low-burden overnight urine samples in 30 postmenopausal women. Methods: Women consumed usual dietary intake during day 1 and usual intake plus a sugar sweetened beverage during day 2. Weighed, photographed food records assessed intake. Enzymatic assay measured U-Suc and U-Fruc from fasting overnight samples; liquid chromatography mass spectrometry (LC-MS) validated U-Suc findings. Results: Dietary added sugars increased significantly during day 2 (p < 0.001), but urinary sugars were not significantly increased. Enzymatic assay detected urinary sugars in 75% (U-Suc) and 35% (U-Fruc) of samples. Dietary sucrose was not associated with U-Suc, however dietary fructose was significantly associated with U-Fruc [β = 0.031; p < 0.05] among women with detectable urinary sugars. Participants with detectable U-Fruc consumed more energy from added sugars [12.6% kcal day 1; 21.5% kcal day 2] than participants with undetectable U-Fruc [9.3% kcal day 1; 17.4% kcal day 2], p < 0.05. Using LC-MS, U-Suc predicted sucrose and added sugar intake [β = 0.017, β = 0.013 respectively; both p < 0.05]. Conclusions: Urinary sugars measured enzymatically from overnight urine samples were not sensitive biomarkers of changing added sugar intake in postmenopausal women. However, urinary fructose measured by enzymatic assay or LC-MS may differentiate low versus high added sugar consumers.
Databáze:	MEDLINE
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