Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis.

Autor: Hawerkamp HC; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin Dublin Ireland., Fahy CMR; Paediatric Dermatology Children's Health Ireland at Crumlin Dublin Ireland.; Royal United Hospitals NHS Foundation Trust Bath UK., Fallon PG; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin Dublin Ireland.; National Children's Research Centre Our Lady's Children's Hospital Dublin Ireland.; Clinical Medicine Trinity College Dublin Dublin Ireland., Schwartz C; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin Dublin Ireland.; Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg Erlangen Germany.; Medical Immunology Campus Erlangen FAU Erlangen-Nürnberg Erlangen Germany.
Jazyk: angličtina
Zdroj: Skin health and disease [Skin Health Dis] 2022 Feb 16; Vol. 2 (2), pp. e99. Date of Electronic Publication: 2022 Feb 16 (Print Publication: 2022).
DOI: 10.1002/ski2.99
Abstrakt: The human skin can be affected by a multitude of diseases including inflammatory conditions such as atopic dermatitis and psoriasis. Here, we describe how skin barrier integrity and immunity become dysregulated during these two most common inflammatory skin conditions. We summarise recent advances made in the field of the skin innate immune system and its interaction with adaptive immunity. We review gene variants associated with atopic dermatitis and psoriasis that affect innate immune mechanisms and skin barrier integrity. Finally, we discuss how current and future therapies may affect innate immune responses and skin barrier integrity in a generalized or more targeted approach in order to ameliorate disease in patients.
Competing Interests: None to declare.
(© 2022 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.)
Databáze: MEDLINE
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