Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors.

Autor:	Rotar O; Almazov National Medical Research Centre, Saint Petersburg, Russia., Boyarinova M; Almazov National Medical Research Centre, Saint Petersburg, Russia., Moguchaya E; Almazov National Medical Research Centre, Saint Petersburg, Russia., Tolkunova K; Almazov National Medical Research Centre, Saint Petersburg, Russia., Kolosov N; Almazov National Medical Research Centre, Saint Petersburg, Russia.; ITMO University, Saint Petersburg, Russia.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States., Rezapova V; Almazov National Medical Research Centre, Saint Petersburg, Russia.; ITMO University, Saint Petersburg, Russia.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States., Freylikhman O; Almazov National Medical Research Centre, Saint Petersburg, Russia., Usoltsev D; Almazov National Medical Research Centre, Saint Petersburg, Russia.; ITMO University, Saint Petersburg, Russia.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States., Melnik O; Almazov National Medical Research Centre, Saint Petersburg, Russia., Sergushichev A; ITMO University, Saint Petersburg, Russia., Solntsev V; Almazov National Medical Research Centre, Saint Petersburg, Russia., Kostareva A; Almazov National Medical Research Centre, Saint Petersburg, Russia., Dubinina E; Herzen State Pedagogical University of Russia, Saint Petersburg, Russia.; V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, Saint Petersburg, Russia., Voortman T; Erasmus Medical Center, Rotterdam, Netherlands.; Division of Nutrition and Health, Wageningen University, Wageningen, Netherlands., Stevens C; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States., Daly MJ; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States.; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland., Konradi A; Almazov National Medical Research Centre, Saint Petersburg, Russia.; ITMO University, Saint Petersburg, Russia., Shlyakhto E; Almazov National Medical Research Centre, Saint Petersburg, Russia., Artomov M; Almazov National Medical Research Centre, Saint Petersburg, Russia.; ITMO University, Saint Petersburg, Russia.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, United States.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, United States.; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 May 23; Vol. 9, pp. 843439. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).
DOI:	10.3389/fcvm.2022.843439
Abstrakt:	Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate. Competing Interests: MD is a founder of Maze Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Rotar, Boyarinova, Moguchaya, Tolkunova, Kolosov, Rezapova, Freylikhman, Usoltsev, Melnik, Sergushichev, Solntsev, Kostareva, Dubinina, Voortman, Stevens, Daly, Konradi, Shlyakhto and Artomov.)
Databáze:	MEDLINE
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